please bare with me Im knew here but I have been fighting RA since 1996 and fybro since 2001 I am taking Enbrel injection for the RA and Cymbalta along with Norco for the Fybro pain the Norco is a narcotic I use only 1 in the am and 1 in the pm just to help with the stiffness and soreness that usually accompanies it and then the pm to help get to sleep after the days activities. Hope this helps. The Combo as with any is not a magic bullet but it works best so far it does take a few weeks for full affect like 4-6 or so.