Does Plaquenil cause fatigue or fever?

Hi Moggy914 - I have RA and my teenage daughter has fibromyalgia. I think fatigue is a big part of everything you have. AT times I have had that debilitating fatigue. My daughter still deals with it - she is housebound. My rheumatologist told me that once the inflammation is under control my fatigue will improve. He's been right. I believe my inflammation is up now and I have been in more pain and experiencing more fatigue. I take Plaquenil along with (prednisone, methotrexate, and Humira). None of these meds make me fatigued. I believe its the illness that causes my fatigue and my daughters fatigue. I suspect that holds true for you too. Maybe someone else will tell you differently, but I haven't known anyone else that found Plaquenil to make them tired. Pace and rest when you can and if you can exercise a little try to do that. My daughter couldn't exercise at all until recently. Now she can just a little. I was able to always exercise even when I was so swollen. It just made me feel good that I did something for me. When I was at my worst I didn't exercise as much, but I kept walking. I did some yoga but some positions I couldn't do. I just prided myself on trying and doing what I could. Oh, a couple of your other meds might make you tired, but I don't think Plaquenil will. Best of luck to you.

Kim