My RA doctor and I had a long discussion about
this because I get a lot of sinus infections. He will not take me off MTX while taking antibiotic (even penicillian) because you are only on antibiotic about
10 days and you would only miss one dose of MTX. It's still loaded in your system. If it becomes a problem he suggests we switch to another antibiotic. The problem for me is what works best so both doctors agree to go with it for 10 day periods. liver test have all been fine with this arrangement.
I think each doctor feels differently about it so talk to your doctor.