Joy, I think I remember you from IBS forum. I cant take tylenol anymore,high liver levels. If I take my Savella Im not suppose to take Ibuprophen or Amerix. My shoulder now has a tear,ddd,busitis,and fluid on rotator cuff and it is really hurting. My neck is now causing spasm all the way across my back. I dont want to stop therapy cause I cant hardly move my neck or shoulder but it really isnt helping. Im taking Amerix or flexeril(cant see that either one is helping) and Ibuprophen and Im not getting any relief. Have tramedol but it says not to take with amerix. MY Rheumy had me take Tramedol, Amerix,Savella,and diclofenac!!!The pain went away after a week and a few hours later I was TOTALLY NUMB!! Scared me to death. I could not even walk. I had got cortizone shot also. Now I am afraid to take meds. I have spent 2 months while on FMLA trying to find a fix and Im not any better. Oh well, must keep trying. My RHeumy says Im just sensitive to meds. My late husband used Feldene and it worked great 10 years ago. Im going to ask for it. Sometimes I think they just want us to try the new meds. going to rheemy Dr. next week. Thanks for the info. Maybe I will try therapy again in a few months.