Methotrexate + Leflunomide=really sick

kdlalib

Regular Member

Joined : Mar 2011

Posts : 55

Posted 7/12/2011 11:18 PM (GMT 0)

I've taken both methotrexate and leflunomide separately, but about 2 wks ago I started taking them together and I'm feeling really sick. I'm taking 10 mg. methotrexate and 20 mg leflunomide daily. The diarrhea and stomach pains have been horrible. Is there any way to reduce those side effects without adjusting the dosage? My arthritis is really severe and doesn't respond to most medications or the side effects are too serious, so I really need this combo to work. Any advice?

Vannie

Veteran Member

Joined : Aug 2010

Posts : 795

Posted 7/13/2011 1:03 AM (GMT 0)

Call your doctor. He/she may have some suggestions, and he/she needs to know what you are going thru. Maybe you need to start at a lower dose of one or the other. Did you start them both at the same time at the current dosage?

Best Wishes,
V

golitho

Veteran Member

Joined : Sep 2008

Posts : 1670

Posted 7/13/2011 5:09 AM (GMT 0)

I was on this mix a few years back and it made me ill too, wiped out my white blood cells. Maybe for some of us its a combination too toxic to handle. I'd speak to your rheumy and let them know whats happening.

Best wishes, golitho

Spicey

Regular Member

Joined : Mar 2009

Posts : 135

Posted 9/3/2011 5:34 PM (GMT 0)

Methotrexate is supposed to be taken only weekly.

Spicey

Regular Member

Joined : Mar 2009

Posts : 135

Posted 9/3/2011 5:35 PM (GMT 0)

Not daily.

Chartreux

Veteran Member

Joined : Aug 2006

Posts : 9664

Posted 9/5/2011 11:07 AM (GMT 0)

Yes, Talk to your doctor as soon as possible...make a phone call to get seen sooner...
well wishes and keep us posted on how your doing...

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