I was on Depakote for 3 days and became very sick to my stomach. I do not tolerate pharmaceuticals well and have a super high metabolism. It did not work for me, but neither did lithium, lamictal, thorizen or seroquel. Just started trileptal, only been on a week, feeling a little better but NO SIDE EFFECTS. My problem is mostly mania not depression though I am a rapid cycler.
Hope you find the right med, do not give up.