mommasox, You didn't say how long you've been on the Lithium and Effexor. If it hasn't been 4-6 weeks, it's too soon to see results in bringing your moods under control. I am also on both, I've been on Lithium for 15 years. I know how this disease plays with your mind. Try to give yourself a goal of on thing to get done every day. Even something small, like feeding and petting the dog. As time goes on, you will be able to expand on this and it will help your mood. And if your kids are in grade school or better, let them know you just don't feel good but you are working on getting better. They can take it if you let them in. Good luck, chesswoman