I have been off of Prednisone for a month now and have done nothing but gain weight. The first of November I had a Ileosectomy and was not able to eat for 10 days. I got home, recovered, and started finally feeling normal again. No pain at all!!!! I started back working out again and watching what I eat and I have been just gaining weight. I don't know what is wrong. I normally can start working out and eating right and w/in a week I start losing. Not this time. I have been working out for almost 3 weeks now and nothing but gain. It took a long time for me to lose my weight, I don't want to gain it back! Any chance of some hormone problems thanks to Prednisone or could it be taking Imuran and Sulphasalazine alone doing it?