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Journal Gastroenterology-- pregnancy IBD article anyone have it?

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Posted 1/16/2008 1:43 AM (GMT 0)
CCFA sent out a short email and article about this study. They summarized that across the board women w/ IBD are at higher risk for bad outcomes in pregnancy than healthy women. Has anyone seen the full journal article? It seems to contradict a lot of the conventional wisdom I've heard, so I am really curious to see it. I hope there are at least some recommendations.


Here's the CCFA link:
Inflammatory bowel disease associated with worse pregnancy outcomes
http://www.ccfa.org/reuters/pregnancyoutcomes
Posted 1/16/2008 5:43 AM (GMT 0)
I think I remember seeing this article discussed on CCFA. I'm not sure exactly which one it is, but if you go to www.googlescholar.com and put in "Crohn's" and "pregnancy" you'll get links to a lot of articles- maybe you can find the specific one? Good luck!
Posted 1/16/2008 10:37 AM (GMT 0)
Hi I saw the artical CCFA e-mailed it to me. I agree with Zazucat about googleing it.
Posted 1/16/2008 8:00 PM (GMT 0)
I have been talking to a high risk ob and my gastro about this subject and from what I understand, this is only the case if your crohns is active when you conceive. 33% of people get better with their crohns and 33% stay about the same-so that is a 66% chance of pregnancy being good. The outcomes are better if the disease is in remission. If the disease is active then you can have a higher chance of having a miscarriage, still birth, low birth weight or preterm baby, but again that's if it is very active. In addition, there are a lot of people that got pregnant with active disease that did not have negative outcomes. I think the percentage is just higher than the population. If someone finds the article, I would love to read it.
Posted 1/17/2008 1:15 AM (GMT 0)
Emmy T, I was told the same things. That is why I am concerned about the article. It is about IBD in general and not just CD, so that may skew things.

I did find and abstract for it at
http://www.ncbi.nlm.nih.gov/pubmed/17764676?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Here's part of the abstract b/c I don't think I am allowed to copy and past all of it:

Mahadevan U, Sandborn WJ, Li DK, Hakimian S, Kane S, Corley DA.
Division of Gastroenterology, Department of Medicine, University of California San Francisco
BACKGROUND & AIMS: The aim of this study was to determine whether pregnancy outcomes differ between women with and without inflammatory bowel disease ... to determine what risk factors adversely affect outcomes.
METHODS: We conducted a cohort study of all pregnant women within the Northern California Kaiser Permanente membership between the years 1995 and 2002. We abstracted the records of all pregnancies in women with IBD (exposed cohort) and a random sample of pregnancies from age-matched women without IBD (unexposed cohort) and evaluated risk factors for spontaneous abortion, complications of pregnancy, and adverse newborn events.
RESULTS: ...Women with IBD were more likely to have an adverse conception outcome, ... an adverse pregnancy outcome, ... or a pregnancy complication ...; however, the difference between the 2 groups in adverse newborn outcomes was not statistically significant. Independent predictors of an adverse outcome included a diagnosis of IBD, a history of surgery for IBD, and non-Caucasian ethnicity. Severity of disease and medical treatments were not associated with an adverse outcome.
CONCLUSIONS: Women with IBD are more likely to have an adverse outcome related to pregnancy. Disease activity and medical treatment did not predict adverse outcomes in a large, nonreferral population.
Posted 1/17/2008 3:14 AM (GMT 0)
You could also try your local med school. They usually subscribe to all the journals. At least my law school has all the law ones. If Sarita is on she might have online access to it and be able to email it to you. I am only helpful at accessing law journals. Sorry!
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