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WHAT???? Two thirds of patients went into remission, 89% responded to tx.

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Crohn's Disease
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Posted 4/30/2008 10:23 PM (GMT 0)
Why isnt there much talk about LDN? Can it be prescribed yet?

http://www.lowdosenaltrexone.org/ldn_trials.htm

"Dr. Smith, Professor of Gastroenterology at Pennsylvania State University's College of Medicine, found that two-thirds of the patients in her pilot study went into remission and fully 89% of the group responded to LDN treatment to some degree"

Posted 4/30/2008 10:26 PM (GMT 0)
Feeling really stupid right now???? What is LDN?

rj
Posted 4/30/2008 10:29 PM (GMT 0)
look at the link....low dose naltrexone
Posted 4/30/2008 10:31 PM (GMT 0)
Its Narcan. What they give to folks with opiate overdoses. This drug has been around for decades and is harmless in low doses.

Low Dose Naltrexone, its not a "new Wonder" drug so there probabaly is not any money to be made.

Has anyone tried this. I start remicade next week and would live to try something a little less harsh.

Posted 4/30/2008 10:56 PM (GMT 0)
Narcan is naloxone. Naltrexone is a different drug.

The big problem with the bright, new, shiny drugs for any chronic disorder is that it's a good idea to wait until there have been at least a couple of rounds of studies. It's good that Penn State has decided to chase this, and I sincerely hope they'll get some good data- AND FAST.

With diseases that tend to undergo remissive episodes like Crohn's, it's much tougher to gauge the efficacy of drugs like naltrexone. A three month study simply won't cut it. Unfortunately, longer studies also means a longer time before it can be handed down to patients.

Let's also not forget that for a chronic disorder like Crohn's, where a patient could spend years or even decades on the drug, some long-term safety data might be very nice. While naltrexone is a safe drug, it's not tough to imagine strange disorders popping up in Crohn's patients on LDN- stuff that might not get caught until 2-3 years after the drug is out there.

That having been said, I'm hopeful that something good will come of it. It would seem a relatively inexpensive treatment. If it proves effective and safe in long studies- perfect.
Posted 4/30/2008 11:01 PM (GMT 0)
canuckgirl in the Lupus forum takes LDN. I've heard some success stories from those with Lupus and MS. If you go to the top of the page and type in LDN in the search window, you'll find lots of posts about it in the other forums. Blessings!
Posted 4/30/2008 11:26 PM (GMT 0)

LDN is not FDA approved yet in low doses for Crohn's. There is an ongoing study at Penn Univ. that Crohnies have been discussing here. Not sure about the long term affects yet of this drug.

Posted 4/30/2008 11:27 PM (GMT 0)

On the next page of this Crohn's forum, you'll see this topic with 2 pages of responses. (originally started by Ingrid of Norway)

Penn State University and Crohns Disease

I know there are folks on some of the spondylitis forums who are using LDN with success as well.

Jan

Posted 5/1/2008 3:08 AM (GMT 0)
You have to remember that there was no placebo and it was a very small number of patients. I wouldn't be surprised that if they had a large multi-center controlled trial, less than 50% would go into remission. It had no effect on me (like everything else).
Posted 5/3/2008 9:31 PM (GMT 0)
I know a lady who I talk to on dailystrength.com and she started LDN a few months ago and went from 15+ BM's a day down to 3 and she has no pain. I'm hoping I can get my hands on it, but it's a little harder up here in Canada where doctors are really strict with what they give out. I have a few docs up my sleeve so hopefully one of them will prescribe it to me.
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