A1 milk - the cause of Crohns?

Thanks for posting that! I'd read an article a while back about it. The article mentioned that we will eventually see A2 Protein Certified milk on our shelves. I've been watching, but haven't yet seen it... Have you run across anything that states what kind of cow produces A2 milk?

Goat milk is A2 milk. Costs too much money for me though! Also, I believe it's jersey cows that produce A2 milk.

Mag I also started smoking at the same age too. That has been another thought that might be the culprit for my Crohns. None of my siblings smoked, only me. Hmmmm....

There is crohn's in mexico as there is in pretty much every corner of the world, it's just that the highest prevalence is in North America...

this link gives aprox numbers....

http://www.cureresearch.com/c/crohns_disease/stats-country.htm

:)

i read a lot about the MAP bacteria a while back and it seemed milk was the main culprit in that theory too...i know i drank a lot of milk growing up, but i wasn't breast fed. actually, when i was in the hospital for my resection last year one of the nurses asked if i was breast fed, and felt very strongly that if i ever have kids i should do that because it helps to line the guts...i felt like she was blaming my mom for my bad guts :S on another note, i've never used tobacco in my life, but it doesn't mean that couldn't be a cause for some too....i also read that birth control has been looked at as a trigger...who knows?

I wouldn't trust that link PB4, at least not in regards to its predictions of Crohn's in other countries. I thought some of those numbers looked a little weird, so I started reading the top part. All they did is take the estimate for Crohn's disease in the U.S. (0.18% of the population) and adapt that number to the population of all other countries, which assumes prevalence of Crohn's does not vary across country, continent and ethnicity (among other things). Research has conclusively shown that certain races, ethnicities & nations have higher rates of Crohn's -- whites, certain types of Jews, and developed nations.

Honestly, I'm disheartened that this kind of site even exists, as it is very misleading.

the Casein molecule: http://www.betacasein.org/index.php/pi_pageid/92
BCM molecule: followed by a numeral indicating the number of amino acids in the sequence is now, either the byproduct, or, the actual [smaller] chain of casein that has not digested I'm not quite sure.
http://ajpgi.physiology.org/cgi/content/abstract/290/6/G1105 what this tells me is that rats can't digest cows milk either.

human BCM7 (Tyr-Pro-Phe-Val-Glu-Pro-Ile) differs from the bovine form (Tyr-Pro-Phe-Pro-Gly-Pro-Ile) at two amino acid positions. <<<Now this is referring to the reminder of the casein from digestion and I no longer see the histidine?????? I see Val for humans and Proline for the cow,,, or is this a misprint??

Can someone explain where the histidine went? from wikipedia : http://en.wikipedia.org/wiki/Casomorphin

Casein products like the Ensure drink,, protein powders, etc (theres alot of food with casein) some have these amino acids in short form and was wondering if its [already] the histidine or the byproduct, which is the problem.

Human digestion may break down casomorphins into inactive dipeptides by the enzyme dipeptidyl peptidase-4. DPP4<<<< and so now here when the enzyme attempts the digestion there are potential genetic problems. http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102720

http://jag.igr.poznan.pl/2007-Volume-48/3/pdf/2007_Volume_48_3-189-198.pdf


The above link shows the breakdown sequences.

Not one single person in my family has Crohn's but I do. Mostely everyone I have with Crohn's has someone
in their family with it as well. I always thought it was odd that I don't. I was also a smoker and started having
problems a few years after I was smoking. That's interesting. I never thought about that but maybe could
be reasoning for me. I also got very sick with mine after my first husband and I were trying to get pregnant
and I was taking all kinds of fertility drugs. I had another friend that tried for years to get pregnant, finally
went the fertility route, and ended up with Colon cancer. She lost her battle last year. She left behind a husband
and two small children. So I often thought maybe those fertility drugs I took stired it all up.
Its so hard to tell. I quit trying to figure out how I got it and just live with the fact I have it, and I'll deal
with it.

of course noone wants to prescribe a narcotic so you can digest the milk protein better.

Perhaps I have compounded the issue. I assumed the mechanism of protein digestion is flawed and that the variants can somehow be helpful to understand the flaw.

Here is another site: http://www.nutramed.com/eatingdisorders/addictivefoods.htm

"From our basic understanding of protein digestion, we should predict that there will be regular traffic of peptide information passing from food digests into the body. Ingestion of normal food may result in information-molecules streaming into our bloodstream from stomach or small intestine with all the impact of narcotic drugs! A "Gluten Stimulatory Peptide" is also described with narcotic (opiate) antagonist properties. It has been suggested that gluten hydrolysates, digests of wheat protein, have mixed opiate agonist-antagonist activity and, like two drugs with mixed narcotic activating and blocking actions (nalorphine and cyclazocine), produce dysphoria and even psychotic symptoms. Loukas and colleagues have derived the structure of cow's milk-derived exorphins: Opioid activities and structures of casein-derived exorphins. These two peptides carry information by finding and binding to brain receptors which ordinarily respond to endorphins. The message is go to sleep, feel bad, but go back for more.

Arg-Tyr-Leu-Gly-Tyr-Leu-Glu (exorphin, digested from alpha casein)

Tyr-Pro-Phe-Pro-Gly (exorphin, digested from beta casein)

The question becomes, how does this information benefit a person with crohns. As the agonist-antagonist activity has not been specified above, for crohns.

When I'm not so tired I'm going to have to look into this line of thinking a bit more.  But right away I'm seeing a connection to a hypothesis as follows...

Some protein source is providing an opiod peptide that causes crohn's.  I'm not sure if an opiod peptide is a "real" thing at this point cause I've done no reading or if it's a theory...but in any event the fact that it's opiod like was supported by the fact that an opiod antagonist prevents effects....

So it would maybe be an opiod antagonist that would be the treatment for whatever protein, opiod peptide causes crohn's...in theory, of course.  I think it's a very interesting thought and am definitely going to do some reading on it tomorrow...

I don't think codeine with tylenol would be similar to cyprodime, but I do think that there may be an opium antagonist in lomotil.

 

 

medchrt1 said...
I have a chemical engineering degree tsitodawg thanks for compliment.

The statement from the rat reference: http://ajpgi.physiology.org/cgi/content/abstract/290/6/G1105
..."Interestingly, these effects were prevented by pretreatment of the cells with the µ-opioid antagonist cyprodime."

Indicates that if cyprodime is used, less mucous is created (when the BCM is in the bowel), and I would support this as follows: codeine (similar to cyprodime ??) is one of the few drugs that helped reduce symptoms for me. either in the codeine with tylonol or the lomotil.