My liver enzymes have been high on and off for years. We ended up stopping 6mp because they were so high and it wasn't helping anyway (not at a therapeutic level). I've had an MRCP, ERCP and liver biopsy and they all showed inflammation in the bile ducts. They've stayed pretty low in the last year or so except for when I was on methotrexate, so I had to stop it also. So no, you aren't alone.