pred caused me the worst constip. when I had to go I couldnt' get rid of evrything, didn't feel like I emptied out my bowels, which caused major problems for me, I would feel a gas bubble coming and great I can get rid of this gas and it would just rumble around and not let me get rid of it, the worst for me, I was on heavy sleep med's, and serax for anxiety, that stuff would not wear off, wierd drug, I lasted 4 months on it and took myself off, slowly, my gi agreed. I use vicodin now for flares and slow down bowels if I go more than 5 times in am. plus rem