I have been on Humira for three years. I used my thighs for the first year or so, alternating sides and
locations. I now use my stomach, you can use the area all around the belly button, and I alternate spots each time. I know I have used the same spot twice, but try not to repeat for several months. If I let the pen sit out for a good 20 min. or so and warm up it really makes a difference on the amount of pain. I find the pen easy to use, but have not tried the syringes yet!
Good Luck!!
Anne