Should I try methotrexate?

Think you may as well give it a go. I think it would have been better starting it at the same time as you started Cimzia, but still, hopefully it will do something.

I would recommend going on the highest dose for Crohn's (25mg), and taking it in injectable form. I've read that the oral tablets make people more nauseous than the injectable stuff. Speaking for myself, I was on methotrexate for a couple of months. Apart from making my haemoglobin drop to 7, it didn't have any other bad side-effects: I felt a bit rough a day or two after the injection, but not so I couldn't function. I wish I could say it worked for me. It didn't, but by the time I'd tried it, I'd already been on Remicade for nearly a year and failed that.

When you next see your doc, I would ask him about Vedolizumab. I think if you could take Vedo in conjunction with methotrexate, it would be more likely to work. Remicade is good, but it is just another anti-TNF, like Humira and Cimzia.

I did Methotrexate injections with Remicade. The only side effect I had was some very minor hair loss in the beginning, and it wasn't noticeable at all, which eventually stopped. Unfortunately the combo stopped working for me as well, so I'm not on them anymore.

Are you worried about the Methotrexate side effects or of the combo? Since we don't have too many options as far as drugs, maybe it'd be worth a shot of adding the injectable Methotrexate with Cimzia before moving on to something else. I feel like it's best to exhaust all our options to the fullest before we move on. If that doesn't work then you could do Remicade with Methotrexate which would help you from producing antibodies to Remicade. Hope you find something that works well for you!