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Experience with Vedolizumab (Entyvio®)

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Crohn's Disease
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Posted 12/26/2014 5:24 AM (GMT 0)
Has anyone had any experience with Vedolizumab (Entyvio®)?

Thanks
Posted 12/26/2014 2:17 PM (GMT 0)
Hi Bandit,
I am on Entyvio along with 6MP. I started initially with Entyvio in October. At some point my Dr. added 6mp.
I am currently at about 8 1/2 weeks since my first treatment. I would definitely say I am responding to the plan. Doing so much better. Less urgency, less trips to the bathroom, minimal blood, hardly any tenesmus. Yesterday I had only 1 trip to the bathroom. This I s amazing as I was in a horrific flare which started in august.
Entyvio has a slower mode than lets say Humira -which I was on for 7 years.

Are you and your Dr. considering this treatment? It is easy as it is given as an infusion - takes about 1/2 hour. It is given at weeks 0-2-6 then once every 2 months. So far I haven't had any adverse reactions.
Posted 12/26/2014 2:40 PM (GMT 0)
I have been on Entyvio since July and have had 5 infusions. I had surgery in April which put me in remission, so I can't really say how effective Entyvio is for me. My doctor is using it for maintenance, and I am still in remission and doing very well. Everyone is reporting that it takes a very long time to start showing results, many weeks or even months. That is comparable to Imuran/6-MP but much slower than Remicade/Humira, which can show results in days.

I get fatigued the day of the infusion but other than that no side effects. However, in infusion 4 I had an allergic reaction - coughing, wheezing, trouble catching my breath. Benadryl fixed it. For infusion 5 I pre-medicated with Claritin. I still had a minor reaction; my doctor thinks steroid pre-medication should nip it in the bud next time. Based on clinical trials and anecdotal evidence, infusion reactions to Entyvio are rare, so you shouldn't be too concerned. They are far more common with Remicade.
Posted 12/27/2014 3:01 AM (GMT 0)
This is for my son. We are considering it since everything else has failed. We are running out of options.

Just worried about side affects similar to those reported for Tsyabri.
Posted 12/27/2014 4:56 AM (GMT 0)
Check out fb group Entyvio warriors.
Posted 12/27/2014 7:43 PM (GMT 0)
No need to be concerned about PML, which is I presume the Tysabri side effect you are talking about. There have been no reported cases of this with Entyvio. It does not cross into the central nervous system like Tysabri does.
Posted 12/27/2014 10:27 PM (GMT 0)
Thank you for the info Bania. My son just came home from the hospital today. Influenza A played havoc with his CD. He also had pancreatitis and positive for Cdiff. Second time he spent christmas in the hospital.
Posted 12/30/2014 4:07 AM (GMT 0)
Glad your son is back home and hope 2015 is a much healthier and a happy year for you both.
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