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Redhill to anounce rhb-104 (anti-map) trial results in three months.

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Posted 5/14/2018 6:33 PM (GMT 0)
Redhill to anounce rhb-104 (anti-map) trial results in three months.
https://www.reuters.com/article/brief-redhill-biopharma-says-last-patien/brief-redhill-biopharma-says-last-patient-assessed-for-main-goal-in-late-stage-crohns-disease-trial-idusfwn1se0pi
Posted 5/14/2018 7:56 PM (GMT 0)
xy, if you will look at the 5th post below & see IPoop's post, he has provided a link with the full article on this.
Posted 5/14/2018 10:42 PM (GMT 0)
Thanks. I didn’t see that before posting.
Posted 5/15/2018 12:05 AM (GMT 0)
Looking forward to checking this out. Thanks @xy123. You're the best one on this forum for posting about new therapies.
Posted 5/15/2018 12:22 AM (GMT 0)
It can't do any harm at all to have an alternative to the biologics, but I'll reserve my judgement for when the results are announced: I hope they are good.
Posted 5/15/2018 8:22 PM (GMT 0)
RedHill Biopharma - RHB-104 Crohn’s Disease Webcast (May 15 2018)

ir.redhillbio.com/static-files/39b8b461-a77c-4eea-9db0-b3154b22ef86
Posted 5/15/2018 9:48 PM (GMT 0)
during the q&a this morning there was some exchange that made it sound like the initial remission results were not that good but I didn't quite understand it...something like a "treatment effect" of 15 percent where they were hoping to see 40...
Posted 5/17/2018 3:39 AM (GMT 0)
I just copied this from Juiles post on another site (human Para Org) as it was some good information in regards to traditional antiMAP treatments. I guess one might expect or hope to see results in the 15-30% rate maybe. Not sure. Higher would of course be awesome, but hopefully they at least have better rates than biologics.

As well, it is only 26 week results. Many on traditional have upwards of a year+ on triple abx I think. But I recall Dr. Chamberlin saying that by 6 months (26 weeks) they usually know if the person is going to respond well and at this point they start to see the turning point in their disease by continuing the abx for another 6 months to indefinite. The 10-15% miracle responders mentioned below I think have a very rapid response with quick relief of symptoms.

Traditional AntiMAP Treatments:
"From what I have heard, Dr. Borody has pretty high success rates, but he individualizes treatment. Dr. Chamberlin had about a 50% remission rate (with 10-15% miracle responders), and additional 20% improved but didn't reach remission, and the rest either had such horrible side effects they couldn't continue, or they didn't respond."

Borody stated that he has really good results when combining Remicade along with triple ABX in his interview.
Posted 5/17/2018 1:30 PM (GMT 0)
I don’t remember the details of the rhb-104 study design, but I think they were testing the patients for map infection. If, when the results are published, we don’t see an impressive response and remission rate with those who were tested positive, that would be very disappointing - primarily because that would imply the falsity of the map hypothesis as the etiology of Crohn’s disease. That’s because this study and the treatment is designed very well; unlike the Selby et al. study.

Post Edited (xy123) : 5/17/2018 7:33:34 AM (GMT-6)

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