I have been on Humira now for about
a year and a half. It has been a wonderful help and relief to my Crohn's. I feel the best I have ever felt in 16 years. I take the shot at night, once every two weeks. First I take two benadryl. I wait about
an hour and then take the Humira shot. It does sting a bit, I won't lie to you. If you take the shot out of the fridge about
15 -30 minutes prior, it's not as bad as the cold stuff. After, it stings for about
a minute. Then I have no pain at all. The next day I do have some mild reddness and swelling which goes away after 24 hours or so. I wish you luck--may you have the good results I have had!