It took about
a month and then all of a sudden I felt terrific. It's not a cure-all tho, I had another flare one month later that lasted two months then I had three good months and two bad months. I am considered in remission now and all I take is LDN and probiotics. I thinks it really takes a year to get the full effect, but I was deathly ill when I started LDN and on predisone, which counteracts the LDN. You should give it a try. I take 4mg with acidophilus as a filler. I even have my husband taking 1.75 mg as a preventative messure.