I have been on Humira for 3 1/2 years. I have only used the syringes...I admit, I am a control freak and it seems to me that there would be more control with the syringes than the pens? But not sure, since I haven't tried them.
As a long time user, my best advice is to take them out of the fridge to room temp, ice up the injection area real good, and inject them SUPER slow!! When my husband injects too fast it hurts like heck. Maybe I am just a baby, but typically an easy injection takes about 5 minutes. He also pinches another area of my skin, close to the injection site (I think it helps get my mind off of the site that the needle is in...and it works). I also apply ice as soon as he pulls the needle out of the injection site (this also helps with not having any bruising). Best of luck!