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should i up the dose of LDN?

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Crohn's Disease
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Posted 11/28/2010 5:50 AM (GMT 0)
wanted some advice about LDN dosage. I'm on 4.5mg at night right now. I have pretty good bowel movements in the morning but at night they are loose and sometimes have blood. would it help to increase the dose?
Posted 11/28/2010 12:57 PM (GMT 0)
Yes,I think it's ok to up the dose, some of us, as of Dr. Ian Zagon (one of the sci. researchers in Phd. dr. Jill Smiths team) is recommending to try what suits you the best. You could always reduce the dose, if you'll find no help. Anyway, you may be very well with 4.5 mg LDN as well, you have only used it since 05 this year, and it may need more time to kick in, and this fact could be the reason why it doesn't help you with all the symptoms. IMHO, I would up it, if I find the answer to my question by doing so, - well, then I'll go on by using a higer dose. You could always try different doses, all the way from 1.0 to 10.0 mg. Go slowly, and increase it gradually untill your symptoms are calmed down. Good luck! :-)
Posted 11/29/2010 4:48 AM (GMT 0)
I started at 4.5 mg but decided to change my dose. I decided to decrease first and see what happened. I am feeling better at 3.6 mg. So I think Beesting is right, you have to find what dose works best for you. I have heard some saying 4 or 3.5 works better while others have gone up to 5 or 6 mg and felt better.
Posted 11/29/2010 5:50 AM (GMT 0)
You could also try spacing out doses - two rounds of 3 mg for a total of 6 a day.
Posted 11/29/2010 11:05 PM (GMT 0)
you also might want to go easy on roughage?
Posted 11/29/2010 11:18 PM (GMT 0)
njmom: what's the source for spacing the doses? never heard that one before. I'd figure you would not want to block the receptors once you elevate the endorphines.
Posted 11/30/2010 12:51 AM (GMT 0)
Janicea, Beesting posted this on HW on 11/18/10:

"My dose is 6.0 mg. I started 3 years ago taking 3.0 mg for 3 weeks, then increased to 4.5 mg, in which I used for a couple of years. I decided to up the dose a year ago, used 6. mg a day and took the dose at night. I have now started to take 3.0 mg in the morning and 3.0 mg at night, and this seems to reduce the fatique I have had for years. LDN is working when taken at night during almost all day, but will not be enogh to work untill the next nightly dose. For me it seems to not be enough. When I started to take it twice a day, I feel better, and the fatique has been so much better now. I just need to nap a couple of times a week now, compared to every day earlier. ;-)"

 

Post Edited (njmom) : 11/29/2010 5:55:08 PM (GMT-7)

Posted 11/30/2010 8:28 PM (GMT 0)
The author, Mary Boyle Bradley is leading an online radioprogram on LDN. She first wrote a book: "Up The Creek with One Paddle" which is a story about her husband that has MS and started to use LDN years ago. He was very ill with his MS at that time. Well, she has been interviewing some authorities in the LDN - field at her www.blogtalkradio.com. One of them is Dr. Ian Zagon, who is in Phd. Dr. Jill Smiths team (Penn State University), doing the phase II on LDN and Crohns. (Now doing a pilot on LDN and kids). Dr. Ian Zagon is an authority in this field and has done lab tests on naltrexone years ago. He says in the interview thar it's possible to vary the dose, and test what's good for you, and he tells it's ok to try any dose between 1.0 mg up to 10.mg to find what suits you the best. It's actually now known that many people is doing much better at a very LDN, this means that LDN is kicking in at a far smaller dose than expected. Many people know that they are sensitive to medicines. They may need just minor doses of LDN, which could be less lower than 3.0 mg, I have heard down to 1.0 - 1.5 mg. Therefor it's no surprise that some people may need bigger doses than 3.0 mg or even bigger than the earlier optimal dose which was suggested to stop at 4.5 mg. As njmom has copied and pasted up here, you can read my doses and how I am doing now. I once started lower, but have adjusted during 3 years.

I am not using any other medication than LDN. If I could use any, I would prefer Asacol as a mantainance medicine. I am not able to use any of those that is to heavy on my immune system, because I had a cancer surgery some years ago, and my GI will not let me use any of the suppressors as a maintainance med, it's to risky for me, cause the cancer could return.

But I would anyway suggest for other to use a combo like Asacol and LDN.

I have to admit that I am using LDN and prednisone in very short time spans. If I feel that a flare is starting, I use to stop it by taking a dose of 10 mg most of the days, but for two or three days I am at 40, 30, 20, and then 10 and down to 5 and then tapering to zero. I personally am using LDN when I take 40 mg too, my doctor is ok with that. Also here: please, always ask your doctor for advice. /Bee
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