Advice needed - Remicade, Cimzia + Humira effectiveness

I am on the last of the 3 major biological meds (Humira) as remicade stopped working for me about a year and a half ago, Cimzia didn't help at all.  My belly pain, cramping and diahrea is tolerable but not completely under control.  My biggest worry is where my crohns is at it's worst, the last 6inches of my colon and my rectum.  I am having a very tough time controlling my bowels at night time and i'm having moderate leakage during the course of a day.  Since i'm afraid of passing my bowels at night i wake myself up a few times to go to the bathroom.  During the day i change twice a day but that is really getting old fast because i do have a full time job.

Currently I am on Humira as i stated already, mesalamine/Apriso, cipro, canasa and 5mg of Oxycodone for pain.  Is there something else that can help?  I am getting tired of living off of nutrional shakes and constantly being in pain.  There has got to be another way.

I have been to two GIs but still no luck.  Any suggestions to help? Thanks

I can completely understand how you feel! I have been pretty resistent to medications also but the longest remission came when I paired Cimzia with Lialda. I was in remission for a year. Have you tried Lialda? I started flaring again last week so I am now trying a natural product called Bee Propolis and it has completely stopped my bleeding and I am down to 1 bw a day. I don't know how long it will work on me but I am amazed at how well I am doing after only a few days. If or when you have exhausted all medications, you may want to consider trying this.

You say you are living off of nutritional shakes - are they the only thing you can tolerate right now? Can you tolerate any regular food? I suffer with Crohn's in the colon/rectum too and the leaky thing is really no fun, so I feel for you. IF you can tolerate any regular foods, I would try that. Sometimes the sugars in the shakes really jack me up and make things worse. I find that when I can eliminate obvious sugars (shakes, syrup, cookies, juice, etc) and eat as "naturally" as possible (no food from a box) it helps a lot. I know how dreadful that sounds since when you're sick the last thing you feel like doing is preparing food. I kind of do my own modified version of the Specific Carbohydrate Diet and when I do - it stops the leaky-butt thing.

I'm sorry you're going through this. I'm hoping you find what does the trick!
Stef