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No reason for high faecal calprotecin?

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Crohn's Disease
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Posted 3/18/2013 8:03 PM (GMT 0)
Okay so I am now back from my successful colonoscopy and they got all the way round this time. It seems I have had more or less all the tests they could give me, but still no reason for my high FC results?

Any suggestions?
Posted 3/18/2013 8:12 PM (GMT 0)
Glad that the scope went on fine :) This has been the case w me for several years. All scopes and CTs used to be clean but the FC was high. What about the symptoms?
Posted 3/18/2013 8:34 PM (GMT 0)
Have they looked at your small intestine? The colonoscopy doesn't go past your colon? have they done a ct or barium abdominal X-ray series? Or could they do a pill cam? what is your SedRate? Is is possible that the FC results were a false positive? I don't think I have had the FC done so I don't really know anything, and I have always had bad scopes, but I didn't know my small intestines were so bad until it was too late.
Posted 3/19/2013 1:40 PM (GMT 0)
I have had, colonoscopy's, ct abdomen, camera down throat etc bloods i cant remember if they ever done these when it all started.

I do have ibs already and the investigations started after my stools became loose and i was going 3/4 times a day and loosing weight. I had a FC test which at the time was 217 which sparked all the other tests. Just befor xmas I passed alot of blood when i opened my bowels and had another fc done which came back 197. As far as symptoms go in general, since seeing the dietitan and making my diet 95 fresh food my stomach cramps are less frequant but without help i'm lucky if i open my bowels 1/2 twice a week because of the IBS. Hope that makes sense
Posted 3/19/2013 7:47 PM (GMT 0)
I found this.
Link is at the bottom.
Good luck.
Jan

An elevated faecal calprotectin is not specific for IBD. Any inflammatory process within the
gastrointestinal tract will result in the activation of the innate immune response and release of calprotectin. Faecal calprotectin concentration has been shown in studies to be elevated in many conditions including infection, colorectal cancer, untreated coeliac disease, microscopic colitis and diverticulitis[11-13].

Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to cause significant increases in faecal calprotectin levels within seven days due to NSAIDs induced intestinal inflammation with endoscopic correlation[14,15]. Proton pump inhibitors (PPIs) have been associated with significantly elevated faecal calprotectin levels, regardless of reason for PPI[16].

www.wjgnet.com/1007-9327/full/v18/i46/6782.htm

Post Edited (jan2003) : 3/19/2013 1:58:44 PM (GMT-6)

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