I recently started taking methotrexate. I was on immuran since 2004. I also take humira weekly. I still have active inflammation, so my doc switched me from immuran to methotrexate. I have been on it for 2 weeks, by injection - 25mg. Both times I have taken it, the next day my hands are very swollen and very red. Just wondering if anyone else has experienced this? Is this a know side effect of methotrexate?