I was on it for 2.5 years. I noticed a change in my health almost immediately, about
2 weeks after my loading doses. It worked REALLY well for me. I started to not respond to it about
2 years in - we bumped the dosing and still no change. Finally just went off it.
I am not sure what the normal response time is... but I know that with it, and other biologicals, that you can build antibodies to it over time which is what happened with me.