ignorance is bliss....I only have used the pens, so I don't know if the syringe is less painful or not....what I do know is that I can take the burn from the humira once it is injected....I know that the actual insertion of the needle is painless because it is so quick...I know the burn passes quickly...and I know that I could never ever watch a needle go into me so therefore I could never ever give myself an injection with a syringe, but I can do the pen by myself and even keep my eyes closed as it injects.
The pain is not terrible....and maybe the syinge is even less pain, ..but the Pen is do-able and gives me control and independence.