Hi. I am new to the forum. I have been on Effexor XR for 18 years and it has worked really great for me. However, I believe it has stopped working. I began getting all the feelings and symptoms of Major Depression returning. My doctor put me on Pristiq. He had me quit taking the Effexor XR 150 mg. and go straight to 50 mg. Pristiq. This is my 2nd day on Pristiq and I feel awful. I am dizzy, feel like I can't function at all. Is this normal? Is anyone on Pristiq after taking Effexor XR and it is working well for them? I feel very scared as if I am losing my sanity. If anyone has any help or information for me, could you please reply. Thank you so much.