MTHFR Mutation + Deplin

Laurar,

I don't have any experience with deplin, but just wanted to say how happy I am that you got a good nights sleep and that you are feeling good. I hope that this medication continues to help you. If the anxiety gets too bothersome, maybe the doc can give you something for that.

Best wishes, and thank you for posting.

Hugs, Karen

Hi Everyone,

*Just posted this in the Anxiety forum too*

Thanks for the responses. I've been on Deplin now for 5 days. I have definitely been feeling better, close to "normal" I'd say. Last night i woke up in the middle of the night having what I think was a mild anxiety attack, but I took half a Xanax and it passed quickly. I was then able to sleep again fairly quickly. I think I'll have to be careful since it seems to mildly flare up my anxiety ever few days, but that's really a small issue considering how much better I feel all around. I'll keep everyone posted!

~Laura

Hi, I'm new member. Wanted to reply to your post about mthf mutation and deplin.
Glad you're doing well on it. I'm in australia and l-methylfolate has not been passed by our food and drug admin yet. I heard about the mthf thing and depression thru my sister's naturopathy lecturers at local university. As deplin not available here, I found a 1mg l-methylfolate supplement on line and started taking 6 caps a day, to get close to the dose provided by deplin. Have done this in consultation with my doctor who was keen to work with me on this. This is almost unheard of here as yet.
I have been taking Effexor for anxiety/ depression last few years, zoloft before that. My anxiety had become extreme in last two years. Effexor and daily mindfulness meditation were helping but I was still anxious all the time and really having to work hard to avoid becoming depressed.
After 2 weeks taking the l-methylfolate supplement, I had started to feel alot better, less anxious, sleeping better. Three weeks later I managed to take a trip to a family party in another part of the country and actually had a good time, rather than just managing to hang together by threads - which is how it has been. After 2 months now, I feel so much better. My mind no longer feels like a hollow, shattered mess. I am keeping in touch with friends and family more and handling my chronic pain better as well. I feel like I have my mind back.
The supplement is costing me 60 aus $ for every 20 days supply. Makes me sad and angry that we are so behind here. Deplin or equivalent could be helping lots of people the way it has helped me. Hope it gets to us soon. I am lucky to have financial support from my family (haven't been able to work sev years now), so I can afford to keep buying the supplement. Most people here couldn't.
My advice to anyone thinking of checking it out would be - go ahead. I had zero side effect (am medication sensitive also). I also think that if its going to be something that helps you, you will know pretty quickly- within a few weeks.
Glad to hear someone else this research has helped. Hope there will be more successes for people who are suffering. Thanks also. Good to share my story.

Hi! I am new to this forum.
My dr prescribed Vit D3 10,000 units and 15mg of Deplin for my chronic nerve pain, stinging, burning, numbing sensations, as well as cracking of all of my joints and ringing in the ear. I was diagnosed with B6 toxicity over 2 years ago and since stopping all B6 supplements, have made no improvement. This new dr noticed that I had low folate levels, allergic to sulfur drugs, skin
rashes, high homocystein levels, had pre clampsia and of Scottish descent. NO OTHER DR MADE THE CONNECTION. I live
with severe chronic nerve pain, most of it is limited to mouth (teeth, gums, tongue and facial areas), I also have burning and stinging in my hands and feet. My joints (all of them including my vertebrae crack with the slightest movement). And there is much more...
However, I am unclear about how he feels Deplin can help with this. I hope someone here on the forum can help me understand what is going on.
Thank you Pisces0312

Pisces 0312, I found your comments because my Lyme Literate Medical Doctor (LLMD) just prescribed 7.5 mg of Deplin for me and I was curious to hear about other people's reactions to it.
In reading about your symptoms, it struck me that all of them can be caused by Lyme Disease. I'm certainly not a doctor, and I don't even know if Lyme Disease exists in Australia, but if it does, I would seek out an LLMD and get tested. I say LLMD because a regular MD would most likely not test you correctly. Check out the Healing Well Lyme Forum and I think you'll find a lot of people with Lyme who sound a lot like you.

Good luck and God bless you. No matter what, just keep going.