How long should you give an antidepressant if your feeling no positive change

I have tried so many antidepressant meds this past year and a half for my severe depression anxiety intense fears paranoia phobia etc and none have given me an ounce of improvement what is the longest you should wait and see if a med is gonna help at all? What is the longest time you have been on a med before noticing any improvement at all? Also can one ssri med work for you if many didnt? Please help

Did you ever have it take awhile before you noticed "any" improvement? Also do you think if several ssri meds didnt work another ssri med can work ?

There's a theory about "Brain Plasticity" and Antidepressants that sheds light on why antidepressants take so long to work. The theory is growing by leaps and bounds. If simply making the neurotransmitter available was the mode of action, people would experience relief from depression practically over night. This isn't the original article that I found on the topic, but it's close.

www.learning-knowledge.com/plasticity.html

Theresa,

What does your doctor tell you?

Hugs, Karen...

I know it isn't... But it is the way that it is... Just don't ever give up. Keep hanging in there. It is so much trial and error. And it doesn't seem fair that finding what is right for us is so hard.

It took me quite a long time to find what worked for me. about four or five different medications. But when I did find the right med, I took it for 15 years. Then it went generic, and often the generics don't work the same, so I switched. I have been on pristq for a long time now.

I really hope you find what works for you soon. But if it takes awhile, please keep hanging in there.

Hugs, Karen...

Please all members I know everyone has there on issues and struggles please just send me your positive thoughts and or prayers that I get relief real soon I am suffering very much for a long time now and so badly desire to be well again I feel I have tried near everything