Hi redjeep it's Krista again, I have several things wrong with me , I'm not sure if yours is just for depression. I've tried alot of meds over the years for my symptoms of M.S. and my depression. I also have severe pain from ostioporosis so I take a lot of different meds. And yes some of them make you off balance,but then again so does the disease. All I was saying was my depression was much better. I get the ligh-headed thing in the mornings ,but I was getting that before the cymbalta. I'm having a lot of constipation, but I'm pretty sure thats from my pain killers which I was already taking senecot-s for. Maybe some-one with not as many problems would be of more help to you. I'm sorry I couldn't help you more , feel better, Krista