alike karen went from effexor to pristiq. current dose 200mg, less sedating, i find that it is very conditional on your mind set. keeps a sort of patterned stability, but alike any meds you have your good days and bad days-regardless of any medication. on it around a year. diet is more regular and with keeping a good focus this seems to make it work better for me. still up and down a bit, but better for the change. been on the med merry go round myself. takes time. give the pristiq a chance, it works a little chemically different thus you may need a little more time to reach it's desired effect. wishing you well. jamie
dx, mdd, severe borderline personality disorder