Yes of course my doctor knows I am on Methadone. My infectious disease doctor seems to think my liver is stronger than I do and that the antidepressants would not affect it. But I like to ask people who have hep c for advice as well. I am genotyope 1A and liver biopsy 6 months ago stated f1-f2 fibrosis, my viral load is 17 million but alt and ast not bad. I am thinking my viral load seems so high, I do not want to do anything to make matters worse. Thks for the feedback!