Hi all Ive read posts on here regarding the inability to lose weight whilst on sertraline. I have been on antidepressants for 20 years and this last January decided Id had enough of killing myself in the gym etc with no results. I have been to my doc several times to be told it was my lifestyle not my meds that made me fat. So I stopped taking my sertraline in Jan and took up running. I only lost weight this last week but boy am I thrilled Ive lost 10 pounds! Im running over 20k a week to speed things up. But I just wanted you all to know there is hope and that i wasnt imagining things it was definitely my meds that stopped me losing weight. I am only five foot and was 11st 1 when i weighed in at bootcamp in Jan. Today I am 10st five and its all come off in a week. Ive a long way to go but I know that when I was waiting for them to come out of my system I would have loved to read a positive story so there it is folks dont lose hope :)