Celexa + Wellbutrin. Anybody does this?

Hi there,

In my opinion, your sister could of had a seizure whether she was on wellbutrin or not. It could of very well been a coincidence. So I wouldn't go by that. Though I do understand your fear.

I took wellbutrin a few years ago. I liked it but couldn't handle a therapeutic dose. It made me nervous, but my mind was as sharp as a tack. I didn't take the celexa with it though. I took it with Effexor. And by itself.

about the only way you are going to know anything is by using it. We all have different side effects and reactions from the medications. So it is hard to tell somebody how it is going to work.

I am sorry you have depression and UC. I hope you get feeling better soon.

Best wishes, and welcome to the forum.

Hugs, Karen...

I've been on the Celexa/Welbutrin combo for a few years now. Seems to work for me. For me the side effects of each seem to negate the other...
examples...
C decreases sex drive, W increases
C increases appetite, W decreases
W can increase alertness and nervousness, C calms
So basically it all balances out, if that makes any sense. Again this is what I experience, for someone else it might be different. The stimulating effect of Welbutrin seemed to lessen in time as at first I experienced some insomnia. But I still take it in the morning just in case (I take Celexa 20mg in the evening).

As for the seizure risk of taking Welbutrin, it is definitely a concern but Ive heard 300mg per day is the max dose before it starts getting into the seizure risk territory. I first started at 300mg, but recently asked for a reduction to 150mg, the reason was because of the cost issue more than anything. And after trying that new dosage I seem to still be fine, so my Dr. is continuing me with that.

The idea I believe for combining these two meds is that one acts as an adjuvant to the other, thereby increasing the overall theraputic anti-depressant effect. Of course I am no medical expert, so definitely talk to your doctor about it.

Best of luck.