I've been taking Cymbalta for about 3 weeks. The first 1 1/2 weeks was horrible. I was nauseated, no appetite, very lethargic, no energy, wanted to sleep all the time. I felt spaced out and totally "Out of IT!". I did not know if I would be able to continue with the medication, but I was determined to give it a month. Now I can say that I'm glad I hung in there! My mood is greatly improved & I have more energy. I am calm in stressful situations & can enjoy the small things in life again! My appetite is still a little suppressed, but for me that is a good thing. I am not nauseated anymore. Occasionally, I feel a little tired, but usually it is close to bedtime anyway. I do still struggle a little with getting up in the morning. It takes me a while to become fully awake, but that is getting better as well.