Hi all, I am new here, and hoping that someone can offer me advice on how to help my mother. I'm 39, and I live in Florida with my boyfriend and my two young boys. My mother is 72, and lives in Mississippi. She has been progressively getting worse over the past two years, falling into deep depression. She lives alone (has now for over 20 years), hermits herself away, continually complains about health problems, goes to doctors only for them to tell her there is absolutely nothing wrong with her, they tell her she has all the clinical signs of depression, but yet she refuses to believe them, refuses to take the Lexipro they keep prescribing, and moves on to another doctor hoping they will agree with her that it is something physical that gives her the symptoms(she is convinced that it is her thyroid despite many tests being done that show normal function). She has lost weight, claiming that she just can't eat, she makes comments all the time that she is losing her mind, that any day now she is going to wake up and not be able to think of single thought, only to find herself put away somewhere is a hospital, she wakes up every night at 3:00 a.m. and can't go back to sleep, she calls me all the time, saying that she can't make it through the day without hearing my voice, and I am the only thing that keeps her going, sometimes begging and crying for me to come get her before she "loses her mind", she says she is shakey all the time, can't concentrate on anything, always misplacing things she just had in her hand a moment ago, she makes comments about "next year" and then follows them up with "hopefully I won't be around that much longer"...etc... Yes, when she comes to visit me during her stay, although I do most definately see the waves of the depression symptoms come and go quite frequently, there are still moments when she is herself again, my mom, who likes to be on the go and have fun and do things. My question on here is how I convince her to listen to the doctors and take the medication? She will try it for about 2-3 days, but even then she will cut it in thirds, take it and then claim that she just can't handle the way it makes her feel (dopey) and quit taking it. She also makes the excuse that she isn't going to take something that just makes her "think" everything is fine with her body when it is only masking the real physical problem of what is making her feel this way. I am truly at my wits end. I just don't know how much longer I can go on listening to her when I know she could do something about it, but just refuses to. Through discussions with my much older sisters, and other family members, regarding her past behavior, it has become apparant to me that she has probably suffered with some type of depression her whole life. I truly don't know how to approach this with her as she gets very angry at anyone talking direct with her. My sister who is a Dr. of psychology, spoke with her about a month ago for the first time in 10 years due to an argument they got in, and after 30 minutes on the phone with my mom, told her that in all her years of practice that she was probably one of the most depressed people she had come across.... That she needed to be on anti-depressants, and that the next time she called her, she expected to hear that she had started taking them. That was the last call my mom made to her, and will be. I don't want that to happen with us, as my other sister refuses to talk to her as well, I am all she has left. But truthfully, she is starting to push me away as well with her refusal to accept reality. She will be visiting me next Monday for about 3 weeks. I don't know how I am going to handle having her here again, being so depressed, and needing so much coddling, as my patience is running thin, and I don't want it to cause the end of our relationship! Any help or suggestions, or pointing me in the right direction would be greatly appreciated! Thanks so much!