I was on a high dose of Lyrica for 3 years. Did not help, made me feel lethargic. I quit taking it a year ago. I was put on Cymbalta, worked okay(low dose). My Doctor asked me to go back on Lyrica(low dose) and combine with Cymbalta. I was so tired of being sick and tired so I tried it. It works! I am not so exhausted all the time. I take along with Valium. Take all my meds before bedtime. I have CFS, CPS, Spinal Stenosis, Osteoarthritis, Arthritis in my back, Fibromyalgia and Hypothyroidism. I think I have tried every med out there and this combo is working well for me. If your afraid of weight gain, just eat healthy, no processed foods.....