Rockon, I had to remove the link because it was asking for donations at the end which is against forum rules.
Sherrine________________
The second gene expression study of the year was recently published. Get past the study & I have some summary for you.
"Our hypothesis is that there is an upregulation of immune/inflammatory molecules in the blood of FM patients with a concomitant decrease in pathways related to hypersensitivity and the allergic responses." The authors
Fibromyalgia patients exhibited a differential expression of 421 genes, several relevant to pathways for pain processing, such as glutamine/glutamate signaling and axonal development.
There was also an upregulation of several inflammatory pathways and downregulation of pathways related to hypersensitivity and allergy. Using rigorous diagnostic modeling strategies, we show “locked” gene signatures discovered on Training and Test cohorts, that have a mean Area Under the Curve (AUC) of 0.81 on randomised, independent external data cohorts.
Lastly, we identified a subset of 10 probesets that provided a diagnostic sensitivity for FM of 95% and a specificity of 96%. We also show that the signatures for FM were very specific to FM rather than common FM comorbidities.
Publ. in Clin Exp. of Rheum. May-June 2016
www.ncbi.nlm.nih.gov/pmc/articles/PMC4888802/
CortJohnson wrote at HealthRising:
That was intriguing given that the expression of genes associated with granulocytes (mast cells, neutrophils, eosinophils, basophils) was reduced in the FM patients. These granule containing immune cells are associated with mast cell activation and the allergic response. Some researchers believe they may also be tweaking the nerves and contributing to pain sensitization.
Does the reduced expression of allergic genes mean FM is an inflammatory disease which results in a reduced mast cell activation syndrome? Apparently the authors don't believe so. The evidence in FM trends towards mast cell activation not the opposite, and the authors emphasized three studies which have found an overexpression of mast cells in the skin of FM patients. One of the genes (CPA3) highlighted - a biomarker for local and systemic mast cell degranulation - suggested that mast cell activation (MCA) had occurred. [Mast cells release inflammatory cytokines and many other problematic mediators.]
They found 428 significantly differentially expressed genes in FM and focused on the top twenty. A genetic network analysis found a trend towards an increased inflammatory response with the most significant group of genes associated with allergy and hypersensitivity. The inflammatory hub was centered on the IL-10 gene - a anti-inflammatory cytokine that has been highlighted in chronic fatigue syndrome several times. High IL-10 levels have been associated with attempts to turn down an overactive immune response.
Studies of inflammation in fibro patients here. Over 30. I have not added in the research from 2016, 2017, but put in one study from 2017 to assure you that more research has been done.
/www.healingwell.com/community/default.aspx?f=24&m=2756942Keywords
Inflammation
Fibro
Fibromyalgja
Post Edited (Rockon) : 2/12/2018 4:20:27 PM (GMT-7)