Prednisone not only treats inflammation, it suppresses your immune system activity. It can weaken your immune system, so anything having the capability of doing that has the capability of making you feel better by making your immune system funtion more normally, not masking the problem. The problem will never go away, but it can be controlled with these medications. If a medication can weaken your immune system, it can make your antibody levels drop. If the medication is not working, and you are in a bad flare, and it has been like this for awhile, your test results should show it.