HI! It's really important to flush the PICC line daily, and certainly before administering any IV antibiotics. This will keep the line patent so he can receive the antibiotics.....if the line becomes clotted he may need to have it replaced, which is just another discomfort.....I had my line in for 6 weeks and flushed it daily....any IV cath needs to be flushed.....Good luck to you!
Petma