From what I have been told and also have gone thru, when you start new meds or the meds are working you will feel way worse then better, that is your body indicating the meds are in fact working because they are killing the lyme and releasing the toxins. make sure you take your detox baths, very important, and make sure you drink a lot of water. Even scrub your skin, all that helps release the toxins. Although your body feels worse, try try to mentally put yourself in a place that you know that it means it is actually helping and focus on feeling good that this medicine is go to make you better. hope this helps, stay strong and make sure you have a really good support system around to help you thru these times.