CuredTwice said...
The current most successful protocol against Borrelia borgdorferi (which I cured myself twice with after being bitten both in 2010 & 2012) is a pulsed combo, taken every other day, of Minocycline taken together with Tinidazole for 42 days. Only one oral dose of each need be taken every other day. Typical dose for a 180 pound man would be Mino-100mg + Tind-250mg.
In addition one must add some sort of extract (or raw food or food cooked at no more than 165F) containing natural Amygdalin (not Laetrile) like Pinella, Wild Cherry Bark extract or even 5 chewed apple seeds a day to kill the Borrelia that are not actively reproducing. If 10 drops of the herbals are taken in a tea with the same natural ingredients as Celestial Seasonings Red Zinger Herbal Tea, one will be adding more natural anti-bacterial ingredients to the mix to kill the spirochetes or mature round body forms not in the process of replication. One's goal should be to add 25 micrograms of amygdalin a day to their diet, every day, for the entire 60 days.
The Tinidazole will disrupt the DNA containing round body forms sometimes called cysts or blebs when the DNA starts to generate a new spriochete.
The Minocycline will kill the spirochetes actively dividing.
The Amygdalin will kill the spirochetes not in cell division, they have no resistance to the -CN molecule produced but human cells will neutralize it into thiocyanate if they are exposed to it.
Expect a good herx at 2-4 weeks when the Tinidazole kicks in.
One will get rid of ALL the Borrelia in 60 days this way if the herbals are continued on a daily basis after the antibiotics are taken.
If one adds a daily combo of the 4 ingredients found in a product called TriBiotics (by NutriCology for example), one will eliminate many co-infections also. The ingredients are: Artesiminin,Berberine, Citrus Seed Extract and Black Walnut Hull.
For other digestive co-infections one can add Bactrim and Fluconazole or the equivalent, pulsed as needed.
Good Luck!
Sincerely,
Will Wiegman
Hey will/curedtwice,
I’m writing in regards to your protocol that you say cured you twice. I appreciate the fact that you’ve put this regimen in the public domain and I’m also sure that your intention in doing this was gregarious: you just want to help people. However what struck me the most was the fact that your approach was an evidence-based one. You’ve gone through hundreds of papers to come with your protocol. My main goal of writing to you now is this: you came up with that protocol on the lymenet forums nearly 1 years ago in 2014 and that has remained since then. However, since your original posting many more papers have come with 3 being landmark ones. However, your protocol has remained the same. As someone who also is evidence-based and traverses the medical literature for answers, I think that your protocol can be further improved. If you believe that it can’t, I would appreciate it if you could respond why it should remain the same taking into account the most recent advances.
I would therefore highly appreciate it if you could answer the following questions:
1). Your protocol mentions taking only one dose of minocycline and tinidazole per alternate day. Your rationale in doing this is so that the lyme cannot detect the antibiotics. That does make sense. However, some evidence goes against this. It is well known in the medical field that one pill of any antibiotic is going to reach very low peak tissue levels. Secondly there was this paper in the lancet in 1991 that already talked about
pulsing for lyme way before current research came out. (http://www.borrelioosi.net/foorumi/viewtopic.php?t=832&p=1400). If you go to the link, you can see that the first letter does mention pulsing but mentions that on the day of the pulse, an essential part of success is dependent on “on achieving a sufficient concentration of an antibiotic with a good antiborrelial activity in all affected tissues, and, in penicillins or cephalosporins, on proliferation of borreliae during treatment period. Either one of these factors may account for a lack of therapeutic effect in some cases.” (as quoted on the letter).
As a result, I wonder if your protocol should be updated to increase the individual dosages in order to achieve optimal tissue concentrations? What is your opinion on this?
2). Secondly, your yourself posted this paper from northeastern university that confirms the presence of persister cells and posits that they can be wiped out either with an anti-cancer agent or pulse dosing. Yet the pulses that they used in the paper, the pulse that is used in the lancet letter above, and the pulses in other pulses all seem to differ from what you mention and I wanted to know why this is the case? The northeastern paper (http://aac.asm.org/content/early/2015/05/20/AAC.00864-15.abstract) mentions that lyme pathogens are distinctly biphasic. That is once their spirochetal form is wiped out, some persisters remain. And if those persisters remain, no antibiotic can kill them save anti-cancer agents. But, given enough time, those persisters will convert to spirochetes again and they can thus be wiped out. As a result, the pulse that the northeastern lab uses in 3 days on 5 days off. Even in the paper above, the regimen used is either 2 days on 6 days off or 1 day on and 6 days off. Yet your protocol uses 1 day on and 1 day off.
Is this enough time to make persisters active against? I ask because in 2014, while there was evidence that persisters existed it wasn’t confirmed and your hypothesis was solely based on the fact that borrelia can convert themselves to different forms (cysts etc). What would change given the above research? Should the pulsing doses be further apart?
I’m posting this in both forums just so the chance of reaching out to increases (lymenet and healing well).
Thanks in advance!