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MTHFR result: homozygous for A1298C

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Posted 10/3/2014 4:06 PM (GMT 0)
I just received my mthfr test results and it says I am homozygous for A1298C- 2 copies of this variant but it did not detect C677T. What does this mean for my lyme and babesia treatment (and possible bartonella)? Could this be y I haven't shown much improvement after 1 1/2 years of treatment? Should I take supplements????
Posted 10/3/2014 4:41 PM (GMT 0)
Bump
Posted 10/3/2014 5:46 PM (GMT 0)
Not sure anyone is clear yet how these methylation cycle genes can impact our lyme & co treatments but since many of us are on supplements and abx there are other genes as well that can determine out body's ability to process, or not, various supplements/abx and if we can benefit from various treatments. It is very complicated and still much to be determined especially those of us with A1298C. Up until recently this gene had been dismissed and the focus/research was on C677T. We know how easily drs/scientists dismiss that which they do not yet understand only to find out years later they were wrong.

Right now I do not think there is any focus on how these genes might impact treatment or how they might contribute to our ability to fight these bugs. Dr. Ben Lynch has much about these genes on his website (google) and also has done educational videos on youtube. There are a couple other Drs as well that might come up in the youtube list. For now all we can do is continue to educate ourselves and try to find a protocol that helps and to share our experiences.
Posted 10/3/2014 10:31 PM (GMT 0)
I have the same mutation. My understanding is that because of the mutation, i have a much harder time detoxing which is a really important function, particularly with Lyme and co's. My Dr has me taking 5-mthf, saluna detox (a bunch of them), Methyl b-12, free aminos, liposomal gluthathione. I also took deplin for a little while but it was very expensive.
Posted 10/4/2014 3:18 PM (GMT 0)
Do you feel this is helping you detox? How do you which one is beneficial? What is the name of liposomal glutithione? I am low in glutithione and curious if you think it effective and what brand you take.
Posted 10/4/2014 3:48 PM (GMT 0)
Roxie, what did you do to know you are low in glutathione?
Posted 10/4/2014 11:28 PM (GMT 0)
thanks all for the info! i am very confused though after doing some research online on sites like mthfr.net. It seems that there are protocols designed for those with C677T mutation but no definite protocols for someone with A1298C homozygous. It seems that the most important supplements are active B12, mthf, and active B6. Is this correct? Would a product that has all three of these such as below link be a good choice for an all in one?

http://www.amazon.com/Thorne-Research-Methyl-Guard-Vegetarian-Capsules/dp/B004R47WWY/ref=sr_1_1?s=hpc&ie=UTF8&qid=1412465120&sr=1-1&keywords=thorne+research+methyl-guard+plus
Posted 10/5/2014 3:20 AM (GMT 0)
MethylGuard is a good product. Add it slowly and carefully if you do not know the status of your other methylation genes.

MTHFR A1298C causes the body to have a harder time having enough BH4. BH4 is what the body uses to detox ammonia. Lyme generates ammonia as one of the many toxins it puts out. So the MTHFR A1298C variant will directly impact your ability to detox Lyme toxins.

To address this, Dr. Yasko has suggested taking biopterin, taking yucca root daily (especially with meals containing high protein foods), and doing charcoal/magnesium flushes weekly to mop up & clear out excess ammonia.

More info on her protocol can be found here: www.dramyyasko.com/resources/autism-pathways-to-recovery/chapter-6/
Posted 10/5/2014 11:11 AM (GMT 0)
Thank you Razzle! Reading the website it is very complicated and her protocols include frequent multiple testing which I don't know how anyone could afford. The two tests she recommends under step 2 for the mutation i have is to use (OAT/MAP & UAA) periodically during the process is over $800 for both per test and then the supplements she sells are also crazy expensive and with all the steps she recommends so many supplements i would be spending close to 1000 a month just for the mthfr supplements. I am having a relatively good day so far and it is still difficult for me to grasp all this info!
Posted 10/5/2014 3:47 PM (GMT 0)
Roxie, I'm taking Essentials Pro Liposomal Gluthathione from Wellness Pharmacy (it's a prescription). One of the things I tested really high for was flame retardant, turns out it was my memory foam mattress. I should have known better, the thing stunk when we first bought it. I aired it out for a few days but after sleeping on in for 3+ years it obviously got into my system. I haven't been tested for heavy metals, etc. since my initial test when I started with my LLMD and learned at that time about my MTHFR issue. I'm still dealing with lyme symptoms so it's hard for me to say if all the soluna detox and LG stuff is working. Finding out about MTHFR was interesting as I have always been sensitive to chemicals, perfumes, itc. Walking through a dept. store when I was a kid used to make me physically sick from all the fragrances.
Hope for Now, it is really confusing and overwhelming. I'm using the products my dr. has prescribed and I've also completely switched over to products with no perfumes or dyes. That helps.
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