Staceygar

Hi there,

I, too, just received my test results back from IGeneX and am trying to understand them. I'm waiting on a call back from my LLMD's nurse. I had my first appointment with this Dr. M 11/7/2014 and he ran his own set of tests that I'll find out more about next week. In the meantime, my PCP (who is so helpful) agreed to write the script for the testing through IGeneX. He read through the results and said it's negative to Lyme...However, when I look at it and read other posts on the forum...I think it may be present. Here's what it shows. If anyone has similar results and has responded to treatment, please share your experience and let me know what your treatment course has been thus far.....

IFA, B BURGDORFERI G/M/A 40 units (which the lab calls "EQUIVOCAL")

LYME IgM WESTERN BLOT:
IGENEX IGM RESULT: POSITIVE
CDC/NYS RESULT: POSITVE
BAND INTENSITY:
18 kDa -
23-25 kDa -
28 kDa -
30 kDa -
31 kDa -
34 kDa -
39 kDa +
41 kDa +
45 kDa -
58 kDa -
66 kDa -
83-93 kDa -

IGENEX-ICG-RESULT: IND
CDC/NYS-RESULT: NEGATIVE
18 kDa +
23-25 kDa -
28 kDa +
30 kDa -
31 kDa +
34 kDa -
39 kDa IND
41 kDa ++
45 kDa +
58 kDa -
66 kDa -
83-93 kDa IND

THANK YOU!!!

I'm so glad you got your test results back!! I'm not explaining this well today, so I hope this makes sense!! Sorry!!

There are some things you should know. IND means indeterminate - there is enough of a positive response to keep it from being considered negative, but not enough of a positive response to be considered "fully" positive. The more "+" beside a result means that it was a stronger response, so one "+" means that it's a positive response, although if you had 3 or 4 +'s, it would be an overwhelmingly positive response.

IgM responses are 'created' during an 'active' infection. It used to be thought that they were only created during the beginning of the infection process, but now we know that it's during the 'active' phase of the infection - each time it happens.

The IgG responses are created during the later stages of infection - no surprised for you as you believe you have a long standing infection anyway, right? Or do I remember wrong???

So it doesn't matter whether the bands are in the IgM or IgG slot, they mean the same things:

Band 18 is a flagellin(tail of the bacteria) fragment and can be positive for any of the spirochete (type of bacteria in Lyme and others) infections like Pintas and Yaws, Relapsing fever, Syphilis and a few others.

Band 28 is for OspD (Outer Surface Protein "D") and is specific for Bb sensu stricto (Lyme disease in the strictest sense).

Band 31 is for OspA - (Outer Surface Protein "A") and is specific for Bb sensu stricto.

Band 39 - BmpA (Bacterial Membrane Protein "A") and is specific for Bb

Band 41 is controversial right now on what it means, but I have yet to see any articles that show anything other than it being for Fla B - another part of the tail of the bacteria and it can cross react with other spirochetal infections such as Pintas and Yaws, Syphilis, Relapsing Fever and a few others - just like band 18.

Band 83 and Band 93 are both specific for Bb though

So you can see that you have several Lyme specific bands that are showing up in your blood - and since the only thing that can make those bands show up are Lyme bacteria - congratulations! You have Lyme! But you knew that because you have the symptoms to back up the diagnosis.

So do you have a game plan with your LLMD?

Best of luck and please do update up on your next visit!

I would highly suggest that you start with only one Mino a day and get started with detoxing first, before adding in anything herbal. If after 3 or 4 days you are doing well with the one dose of Mino a day, then add in the second dose and detox.

Once you have that under control, then you can add in milk thistle to help protect your liver - something many here use. I'm allergic to rag weed and that some how stops some from using milk thistle. For me it increases liver pain/fullness feelings.

Then I would suggest that you start another new thread asking about the herbal/supplement that you should add in. Do be prepared for a landslide of answers though!! Each doctor thinks they know what is best and it's usually at least slightly different than what the next doc says! LOL!

There are some basics though: a good multi-vitamin/ multi-mineral supplement; ALA (Alph Lipoic Acid) - a precursor to Glutathione that helps us to detox; Magnesium- because the ground our food is grown in is deficient, so our food doesn't have enough now; vitamin C; green tea is a good antioxidant and helps to heal Babesia.

Kurrykid,
Having all of your tests come back negative for things is actually quite common for Lyme patients! So hang in there, and hopefully your Igenex test results will show positive! Remember, even the CDC tells us :" Lyme disease is diagnosed based on symptoms, physical findings (e.g., rash), and the possibility of exposure to infected ticks; laboratory testing is helpful if used correctly and performed with validated methods."
www.cdc.gov/lyme/