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I got my 23 and me results back. Any one know what this means? Good news?

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Posted 3/26/2015 12:31 PM (GMT 0)
MTHFR Mutations
First we'll look at a few of your MTHFR mutations. According to research, these mutations are important and can be implicated in various disease states.

Great you have no mutations. That's good news. We will skip this step and talk about your Homozygous mutations.

All of Your Other Mutations
Now we are going to look at all of your mutations. You do not necessarily need to worry about all of these mutations, but certain mutations may cause problems in certain individuals. Genetic Genie does not look at the expression of your genes, it only looks at specific gene SNPs. Keep in mind that even if you are homozygous or heterozygous for a certain mutations, it doesn't necessarily mean there is a problem with the functioning of that gene. You have 4 homozygous (+/+) mutations and 6 heterozygous (+/-) mutations.

Here are your homozygous mutations as indicated in your SNP gene table above (not including MTHFR):

MAO-A R297R
MTRR A66G
BHMT-08
CBS A360A
Here are your heterozygous mutations as indicated in your SNP gene table above (not including MTHFR):

COMT V158M
COMT H62H
VDR Bsm
VDR Taq
AHCY-01
AHCY-19
Posted 3/26/2015 1:51 PM (GMT 0)
Also the list of supplements it tells me to take on the Amy Yasko knowyourgenetics.com its in the $1000 range...per month.. There has to be something wrong with that. I only tested to see if I had detox mutations, which I dont.
Posted 3/26/2015 2:13 PM (GMT 0)
I am still new at learning about the gene mutations and MTHFR and all the supps that go with it, but yeah...not having any MTHFR is a pretty lucky card you have there :)

Most of the info I have been putting together, I have read from Dr. Yasko's "Autism: Pathways to Recovery" on her site. Be forewarned though, it is A LOT of info. It may take you some time to get through it all.

http://www.dramyyasko.com/resources/autism-pathways-to-recovery/

All I can tell you from your list above is that homozygous means one copy of the mutation (from one parent) and heterozygous means two copies.

The only one I recognize is CBS. I have read that CBS mutations can mean sulfite sensitivity. I found this site very helpful in breaking all of that down:
http://www.learningtarget.com/nosulfites/index.htm

Hopefully others will chime in and help decipher all the rest. Georgia Hunter is pretty knowledgeable on the topic and I know there are a few others, Revive?
Posted 3/26/2015 2:22 PM (GMT 0)
hi lymie mom. Thank you for the response. Its odd about the sulfite sensitivity because Ive taken sulfur antibiotics for a year without any issue.

Should I try other websites and plug in my information? The only one Ive tried so far is knowyourgenetics.com because it was free. Im all for supplementing to correct these mutations but one could not possibly take all the supplements recommended in a day, never mind afford them.

Also Im confused as the descriptions of the mutations say that they may not even effect me or some counter act eachother.
Posted 3/26/2015 3:45 PM (GMT 0)
Genetic Genie is a good one to try. It's also free.

Yeah the Yasko results can be overwhelming. Don't worry about that.
Posted 3/26/2015 3:47 PM (GMT 0)
I did genetic gene as well to get the raw data analysed at first
Posted 3/26/2015 3:50 PM (GMT 0)
http://mtrra66g.com/

The MTRR A66G mutation indicates the need for the active form of vitamin B12—methylcobalamin. You should also consider supplementing with methylfolate, in order to ensure these two vitamins are in balance.

The MTRR A66G mutation is a defect of the methionine synthase reductase gene. A mutation of the MTRR A66G gene results in poor methylation of vitamin B12. Serum B12 levels may be normal in MTRR A66G (+/+) or (+/-) individuals; however, the under-methylation of vitamin B12 may result in elevated homocysteine levels. If you have high homocysteine, it may be due to the MTRR A66G mutation.
Posted 3/26/2015 3:51 PM (GMT 0)
re: CBS and BHT mutations

http://quixoticmeblog.blogspot.com/2013/03/nutragenomics-addressing-cbs-bhmt.html
Posted 3/26/2015 4:15 PM (GMT 0)
thank you sarah. I started reading these sites and now im even more confused lol. The supplementation seems to overlap itself in some areas for example hydro B vitamins vs. Methyl B vitamins.
Posted 3/26/2015 4:49 PM (GMT 0)
We can go through and analyze each gene but that may not be necessary. I think it is better to look at the big picture and see what is going wrong with your system. What have you been diagnosed with, what symptoms do you have, etc Were you diagnosed with babesia?

With the mutations you have listed, methyl B-12 may not be appropriate for you. Protein intake needs to be evaluated as well.
Posted 3/26/2015 5:04 PM (GMT 0)
Per Yasko - "Those who are COMT + often cannot tolerate high doses of any methylating agents. For this reason, I tend to focus more on the use of hydroxylcobalamin B12 or dibencozide (adenosyl) B12"

MethylB12 is a methyl donor, some with the COMT + cannot handle it, or can over-methylate quickly.

This is helpful for understanding the different forms of B12:
http://drbloem.com/2012/09/12/cyanocobalamin-vs-methylcobalamin-vs-hydroxocobalamin/

It explains that hydro B12 is the most bio-active form. I cannot handle the cyano b12 version either sublingual or muscular. Muscular made me feel drugged -loopy and exhausted. It was my first clue to have MTHFR testing done. I did this through a blood test and unfortunately I think MTHFR were the only genes tested. So it is quite possible I have several other mutations.

I have also tried the methyl b12. It worked for a few weeks and then I started having horrible headaches, I was over-methylating. I waited a while and then tried hydro and within 2 days had headaches again, but they were much more mild. Suffice to say, I do not need any more forms of b12 for a while!
Posted 3/26/2015 5:05 PM (GMT 0)
I am CDC positive for lyme but treated lyme bart and babesia for a year with abx then 6 months herbs with no improvement. I do every detox method imaginable so I know that not the issue.

My symptoms are:

Dizziness
Chestpain (anxiety), heart palps
eye floaties
fatigue
brain fog
with anxiety and dizziness being the worst of the bunch

I am currently treating for candida.

My protein intake is high as I am a gym nut

Post Edited (Tbrown2) : 3/26/2015 11:10:15 AM (GMT-6)

Posted 3/26/2015 5:16 PM (GMT 0)
I was a gym nut also but not anymore. High protein with your mutations can be an issue and causing some of your problems. Moderate to low protein would be recommended to prevent hypermethioninenmia. Mutations like you have are often seen in malaria and that is why I asked about babesia. Ever been to a foreign country where malaria was present?

The entire bottom portion of your methionine cycle is compromised. What you eat will make or break your condition.
Posted 3/26/2015 5:20 PM (GMT 0)
No I have never been out of the country. I changed my diet for about 6 months to high veggies, some protein, and no carbs and I didn't feel any different.
In my profession one must keep a highly muscular stature, could mean the difference between life and death.
Posted 3/26/2015 5:32 PM (GMT 0)
the thing that annoys me is when the mutation is +/- meaning it could effect you or it could not. An also the fact that some mutations are there to counter act other mutations.
Posted 3/26/2015 6:00 PM (GMT 0)
Well +/- doesn't mean it could affect you or not. That's not really what it means. It means you have a mutation, but not as strong as a +/+ mutation.

I would try supplementing with hydroxy b12 and see how you feel.
Posted 3/26/2015 6:16 PM (GMT 0)
"Keep in mind that even if you are homozygous or heterozygous for a certain mutations, it doesn't necessarily mean there is a problem with the functioning of that gene." (genetic genie)

Thats what I meant when I said that.

I wish there was more help when it came to this stuff. I feel like all the supplement recommendations are contradicting.
Posted 3/26/2015 11:19 PM (GMT 0)
Have to bump myself Cuz I still need help
Posted 3/27/2015 12:41 AM (GMT 0)
Looking at the big picture, those mutations aren't that bad. You could just be deficient of magnesium or zinc that drive some of the reactions. You could be low on phosphotidylserine and phosphotidylcholine. A urine amino acid profile from Doctor's Data would really help.

I've found that I benefited from once a week iodine dosing, twice a week copper dosing, and I have considered low dose lithium dosing, but that is something one must be very careful on. It took Terry Wahls 8 months of eating properly to begin to recover from her MS and she was eating better than we eat. That means it may take us longer.
Posted 3/27/2015 12:42 AM (GMT 0)

lymie mom x 2 said...
Per Yasko - "Those who are COMT + often cannot tolerate high doses of any methylating agents. For this reason, I tend to focus more on the use of hydroxylcobalamin B12 or dibencozide (adenosyl) B12"

MethylB12 is a methyl donor, some with the COMT + cannot handle it, or can over-methylate quickly

Somebody said...




So Im looking at the suggested supplements and it says the hydroxy form of B-12 but in order to fix the methylation cycle its says I need the methyl version..See what I mean?

Post Edited (Tbrown2) : 3/26/2015 6:52:02 PM (GMT-6)

Posted 3/27/2015 12:52 AM (GMT 0)
^^^^ lol i have no idea how to quote. The "somebody" is me
Posted 3/27/2015 1:13 AM (GMT 0)
Georgia hunter you said my whole methylation system was compromised but then you said its not that bad.

I want to fix it because I still dont feel good. Have good days, bad days, and really bad days.

I dont think its as simple as a mag and zinc deficiency because I have been supplementing those all along and still feel like crap.

Im not doubting what youre saying, this is just my way of asking questions and helps me learn
Posted 3/27/2015 3:20 AM (GMT 0)
Helpful info here! I'm going to look into this soon. So, thanks.

I just wanted to add that sulfite sensitivity is very different from sulfa drug sensitivity. They are not related to the best of my knowledge.
Posted 3/27/2015 9:57 AM (GMT 0)
I meant that the major genes (the ones that cause all the problems) are not affected and that your mutations are all in one area of the cycle. Proper supplementation may be able to alleviate some of your issues. You now know what your genes are, it would be great to know what is going on biochemically. I ran a Urine Toxic Metals and a Urine Amino Acid test from Doctor's Data. They were a little pricey but were necessary to tell me what was going on in my body. In my test, I learned that Methionine, Isoluecine, Cysteine, and several other biomarkers were low while Beta-alanaine and Anserine were high. That told me exactly where my pathway was going and I potentially had GI flora issues. The other test told me that my Cu, Se, Cr, and Zn were low and that I was excreting more Cesium and Nickel than any other metal. I was taking Pectasol-C at the time and had zero urine aluminum excretion. The Pectasol-C did exactly what I had hoped. Without those tests, I would be guessing at what to do. It told me what I needed and once I started taking the right supplements and changing my eating accordingly, my oxidative stress dropped.
Posted 3/27/2015 11:26 AM (GMT 0)
Hey Tbrown2

Have you ever had your thyroid checked? And, I'm not talking about just the TSH test most mainstream doctors run.

TSH is a pituitary hormone and an indirect indicator of thyroid function. Looking at TSH to judge thyroid status is like looking at the odometer to gauge how much gas is in the tank.

Thyroid-savvy doctors know to check the actual levels of thyroid hormone: Free T4 and Free T3. They know that healthy people have Free T4/T3 levels near the high ends of their ranges.

Lyme is known to cause or exacerbate hypothyroidism. There's already an estimated 30 million Americans walking around with undiagnosed hypothyroidism.

Many symptoms of Lyme overlap with those of hypothyroidism....

If you have thyroid lab results to share, feel free to post them here for interpretation. You'd need to post the reference ranges for each result since they vary from lab-to-lab and the results can only be interpreted within the context of their ranges.

No matter what, hope you feel better soon!
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