Pulse Antibiotics - Any Success ?

Dr. Burrascano (retired and now researching) who wrote the very famous guidelines for advanced lyme - cured himself by taking antibiotics for 26 months (2 months past end of his lyme symptoms) followed by 3 pulses. I believe the pulses were six weeks of ceftin followed by a three week break but I cant be sure as that was a secondhand report. He also stated in his guidelines to not start the pulse until all the lyme symptoms come back and then hit it hard with the pulse. He did this pulse 3 times to cure himself. He stated that he had only ever needed a patient (he treated thousand) to use the pulse 3 times.

Author of Cure Unknown, Pamela Weintrub, was a patient of his and used this method. Her husband did not use the method and remains on a single antibiotic to this day (does not treat all forms but just keeps symptoms at bay) as he felt with his job he couldn't allow the disease to take over again before he did the pulse. This is info from her book which was published in 2008 - great read by the way!

Recap on method:
High Dose Antibiotics that cover the three morphing forms of borrelia - take until lyme symptoms resolve. Test blood levels of medicine to make sure it is at efficacious levels.
2. Do this and continue for 2 months past all symptoms.
3. stop antibiotics, wait for disease to get bad again.
4. Pulse ceftin (maybe others?) for 6 weeks
5. Break for 3 weeks
6. Repeat pulse up to 3 times.

However this research in the article you posted suggests that it took 4 pulses for them to get rid of all persisters which would be one more pulse than Burrascano saw in his clinical practice. I wish he was my doc but sigh - he no longer practices medicine.

Post Edited (SLML) : 6/13/2015 4:37:29 PM (GMT-6)

Why can't you pulse right from the get go? Has anyone tried it? Will Weigman had a protocol that pulsed every other day?

http://www.sciencedaily.com/releases/2015/06/150601112236.htm

http://aac.asm.org/content/early/2015/05/20/AAC.00864-15


These came out on the first of this month.

The strategy seems to be keeping the bacteria active to better eliminate them. What the conventional treatment now is taking large doses of antibiotics over a longer period of time to try and get the bacteria in its various states. This finding implies they were not as successful when the bacteria was dormant. It also indicates the bacteria does not typically get drug resistant. So whats the problem? This was done in a dish and if antibiotics could not destroy them head on than what can we expect when they are barried in tissues dormant? No doubt many get well with the multiple antibiotic approach but many have not. This looks like a promising discovery. Plus many antibiotics contribute to making more cyst according to reports.

I know of someone who got well using a similar faster pulse method of one day on one day off with smaller doses of BB barrier antibiotics . The question is what is the ideal pulsing regime. Fast every other day or one day on and 3 days off? Or 6 weeks on and
3 weeks off like I believe Dr B used?

Finding the right pulse combos could really help maximize the teatment.

**** Just a theory say you take your antibiotics on Monday and say it takes the Lyme bacteria 1-3 days to become active and divide. From my understanding it's a slow growing bacteria compared to others. Most antibiotics have a 1- 2 days half life some shorter. The absence of antibiotic in the blood may trigger the spirochete to become active. That's when you hit them with a antibiotics again. If your bacteria is more active and activates say In less than a day you can dose right away. Either way you are smoking them out so you can get them. If they stay dormant during the 3 days you are off. Than you are at a stalemate for that pulse and may have to consider more days in between. At the very least you are giving your body a break from antibiotics and that's a win. I'm not a scientists but do have a medical background and this makes sence. The question is what do you do if you have coinfections? Would this work for Bartonella? Or a condition that is constantly progressing? Could you run an antimicrobial herb underneath the pulse to keep the Bart in check while you pulse? In doing so you would also be reducing the Bart on the days you are taking antibiotics. Not sure how it would apply to babesia? Also was told that you need to do a cardiovascular exercise when possible to maximize you antibiotics intake into the capillaries 10 min thirty min after taking the antibiotics.

Thanks to W. W. Who was kind enough to share this valuable information. The basic premise is his work and i take no credit for the time and effort he put into this. Will I appreciate your efforts and the time you spent with me to explain it. Eternally greatful.

Post Edited (Cardinal&Gold) : 6/13/2015 5:47:36 PM (GMT-6)

The pulsed protocol I used was every other day for 45 days. However, that was an average, sometimes if no symptoms occurred on the second day I would wait until the third day when I would wake up with symptoms, then do the doses of Mino/Tindy.

Plus I made sure to get enough Amygdalin in my system to that my Immune System was running at 100% efficiency, about 25 - 50 micrograms a day from sources like Wild Cherry Bark Extract and apple seeds from one apple or 3-4 apricot kernels.

I remain totally symptom free to this day 3 years later!

ww

Post Edited (CuredTwice) : 6/13/2015 5:08:41 PM (GMT-6)

This does make sense.

I would imagine something like Doxy you would want to wait a couple days at least since it has a long half life.

LymePickle - it may prove after time that combo treatment isn't necessary but for now. I would rather be safe than sorry so I am on the combo therapy that Dr. Burrascano recommends in his treatment guidelines. It would be great if, in the future, we were able to shorten the duration of chronic lyme treatment with targeted and effective pulse therapy. Minocycline and Tinidazole is a great combo. Love your insight and information.😄

Post Edited (SLML) : 6/13/2015 11:37:39 PM (GMT-6)

I pulsed abx last year for about 9 months after taking abx every day for awhile. Three weeks on, three weeks off. It was very effective but hard to get through the first few cycles. My adrenals took a beating. I moved on to herbals, Transfer Factor, and LDN.

This makes sense to me.
Key points:
If a SpiroSpirochete is dormant and is active
only once every 3 to 6 weeks than that's only 12 major opportunities to make a major dent.
More pulses crates more opportunities each weak and has to improve the odds.
In this study they hit the bacteria head on with antibiotics in the cyst form in a tube and it didn't do much. So them hiding in the body has to be even more difficult.
I agree this looks like the future.
Maybe they will add an agent that can make them active
so the antibiotics are more effective. Instead of trying to
brake trough their biofilms. Pulse them or entice them to
come out on their own.

Perhaps modify the antibiotics with a bifilm so the spirochete can't detect it. Fight fire with fire!!!

***** current therapy is to try and go get them in their current form for many this means months and years of antibiotic*****

Post Edited (Cardinal&Gold) : 6/14/2015 9:40:43 PM (GMT-6)

CuredTwice - how soon after tick bite did you start your 45 day pulse?

I am seeing Dr. J in DC and he has me pulsing the exact same way as wildlyme, but with slightly different meds. I started a thread on this a while ago but some of the advantages to pulsing are:

Lyme is a slow growing organism, pulse therapy includes:
a) Pulsing to avoid over toxicity, but allow higher dose and or larger number of synergistic antibiotics without toxicity
b) Week off to allow immune system to strengthen
c) Allow cysts forms or hard to access forms to come out and therefore be killed
d) Slow growing Lyme has 4 week lifecycle so by skipping a few days or even a week, the Lyme can still be killed.
c) Many ways to pulse, some use MWF; some use 3 days in a row. Everyone has their reasons but there are clearly many effective approaches as these clinicians who pulse are all well known for effective treatments.

So in short, you are letting your immune system take over slowly or at least start to recognize the bacteria.

bump ^^^ i am wondering this tooo and what is the best to attack the "cyst" form?

QuestIon: How do you beat someone who cheats?
Beat them at their own game.

Is it possible to bifilm antibiotics? Maybe not literally but make them undetectable in the blood?

Maybe someone could do reseach?