MTHFR gene mutation, the journey thus far. EVERYONE GET TESTED!

Old topic - Bump.

Has anyone of you tried Thorne Research Methyl-Guard? Serving size is written for 3 capsules, so 1 capsule contains of:
6.8 mg B6 (as P-5-P)
0.4 mg folate (as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)
0.4 mg B12 (as Methylcobalamin)
0.6 grams Betaine Anhydrous (Trimethylglycine)

I've never tested myself for MTHFR, but after reading now all the information about it I would like to make a treatment trial. I would be very thankful if those more experienced in this field would be able to comment about the ingredients of this product. Thank you!

Thanks. I looked into my notes and it turns out that 2 years ago I have already made a trial with methyl-b12 tablets, folapro and actifolate (from Metagenics) - I didn't feel much of it. At the same time I understand that lack of a reaction to the vitamins is not a proof that I may not have these genes mutation as only testing can determine it. By the way, I made some more reading and it seems that everyone should be very careful with P5P as it may cause very serious and long lasting neuropathy if the dosage is too high. Just a word of caution.

You can easily get customized suggestions for supplements for MTHFR and any of your related defects from here: [ur]http://www.knowyourgenetics.com

On this site, you may input your 23andme results and then download/print out a customized analysis with supplementation recommendations based on your results that you input. I believe the engine that processes this is done by Yasko or people based on her most recent work.

You can get a 15 page customized to your genes Simplifed Supplement Protocol (gird your loins, because it’s not that simple but it’s understandable if you wade through it and check out the ingredients to the links to her products). You will also get a 53 page Methylation Pathway Analysis.

She considers other mutations like CBS and COMT to be more important to address than MTHFR. Also check out the info about MTHFR and other gene defects on www.heartfixer.com/AMRI-Nutrigenomics.htm#MAO%20A:%C2%A0%20Monoamine%20Oxidase%20A (done in 2008, an eternity in the genetic world, but his info does reflect Yasko’s opinion as well).

Both Yasko and the doctor who authored this page recognize that a certain combinations of COMT and VDR Taq which DO NOT tolerate high levels of methyl donors (like folate). These individuals do better with other forms of B12 then Methylcobalamin like Hydroxycobalamin and minute amounts of folate. Heartfixer also puts a game plan in place based on several important mutations.

You can also take your 23andme data, go on geneticgenie.com and have it input into their system for an analysis, but there are no supplement recommendations. someone else in the business noted: Genetic genie is 2 years outdated in what is being analyzed. It includes only the Yasko-related genes from more than a decade ago. Nutrigenomics has come a long way since.

While that’s true, I think one ought to look at as many sources as possible to help and certainly dosing and supplementing is the most difficult problem. I cringe when I see/hear of doctors prescribing massive amount of Deplin (only folate) and not supplementing with B12s or other B cofactors. Good luck.

All I did was break up your post so that it is easier to read by those with Neuro Lyme and troubles with their eyes and make your links into hyper-links

Post Edited By Moderator (Traveler) : 8/7/2014 2:21:52 PM (GMT-6)

Hi Bartelsp - welcome to our community!

When you have a moment, you might want to take a look at the "New to Lyme?...Start Here!" thread at the top of the page - it's full of great information - including symptom lists, detox ideas, and more.

I can't help you with the 23andMe report...but someone with knowledge should be along in the morning to help with that.

Once you get the 23&me report, you can upload it to a site like "sterlings app" to get the info you're looking for. I also ran ours through "genetic genie" it had great methylation and detox reports too.