Lab Results

Could someone please explain these results to me. I received them today and being the weekend, can't get in touch with my doctor.
IGM


18kDa. -
23-25 kDa. + -
28 kDa -
30 kDa. -
31 kDa. -
34 kDa. -
39 kDa. -
41 kDa. +
45 kDa. -
58 kDa. -
66 kDa. -
83-93 kDa. -


IGG
18 kDa. -
23-25 kDa. -
28 kDa. -
30 kDa. -
31 kDa. IND
34 kDa. -
39 kDa. -
41 kDa. IND
45 kDa. -
58 kDa. -
66 kDa. -
83-93 kDa. -

No one understands these results?

Yes. I've started treatment with antibiotics with my LLMD. I wanted to get someone else's input on whether I tested positive with my symptoms. Using antibiotics orally, eyes, and sinuses. Plus thyroid, Hydrocortisone, and Testosterone. Nystatin and Diflucan too.

My adrenal glands aren't working properly.

OP-it's a holiday weekend. There have not been a lot of responses to any posts. There are always a ton of looks vs responses that's normal. People are much more comfortable lurking than posting.

If you looked at the link I provided it gives band by band information. Farther down the page she has taken and responded to ton's of questions which might answer some of the questions you have.

Test results are kind of cut and dry. There isn't much interpretation. Bb is Lyme These are the bands you were +
23-25 outer surface protein C (OspC), specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection

If you were taking oral steroids for any length of time before you did the blood draw that would have blocked your immune response which is what the test is looking for-antibodies.

OP - I agree with jrpsf - People are often busy on Long weekends.

But, I have to say that sometimes when a thread is started, there aren't a lot of replies...it's happened to most of us. I've had to bump my own up due to lack of responses several times. There are so many new threads started each day now that the forum is busier...that they often fall to Page2.

The other thing is - many people aren't comfortable with interpreting lab results.

When you have lyme disease - because often the immune system is suppressed - that any activity to the lyme specific bands is significant. And, as jrpsf stated - band 23-25 is specific to Bb.

If those results came from Igenex, I would suggest that you call them Tuesday and request that the doctor on their staff call you to discuss. My results were similar to yours and I was surprised at how adamant the lab doctor was about making sure that I realized that reactivity to "lyme specific" bands meant that I had definitely been exposed to the lyme bacteria. Combined with on-going symptoms it leaves little doubt. Interestingly...his very first question was if I had undergone any steroid treatment. (Which I had) Apparently it is not that uncommon for them to see limited reactivity when that is the case.

I am confused by your +- next to 23-25 . Is that supposed to be ++ ?
23-25 is lyme specific I believe....

Post Edited (B777) : 9/6/2015 6:36:25 PM (GMT-6)

You are CDC positive by IgM if my interpretation is correct.

As the others have said, this is a long holiday weekend - and I personally just had to take a day off from the forum - which I rarely do.

On to your test results - here is the site that I use to help interpret them:www.reocities.com/HotSprings/Oasis/6455/western-blot.txt You can go there to find supporting Pubmed articles showing what these bands represent.
An IgM result means that you have an active infection. It once was thought to mean an 'early' infection, but has since been revised. IgG means that the infection is at a later stage. The more +'s you have beside a number, the stronger the reaction.
IND means indeterminate - not negative, but not quite strong enough to be "fully positive". But it means that you reacted on those bands and should be considered, especially when they are Lyme specific bands.
A "Lyme specific band" means specific for Borrelia Burgdorferi, sensu stricto - Lyme disease in the strictest sense. There is only one on the over 300 known strains of Lyme that is considered Bb, ss. Nothing else will turn a Lyme specific band positive other than Lyme disease.

Bands 18 & 41 (whether in IgM or IgG) are indicative of the tail of the bacteria, which can cross react with other Spirochetal bacteria such as Relapsing Fever, Pintas and Yaws, and Syphilis.

There seems to be some controversy among patients about Band 31, so here are some links to back up Band 31 being Lyme specific:

www.ncbi.nlm.nih.gov/pubmed/1520966



www.ncbi.nlm.nih.gov/pubmed/9440203



www.ncbi.nlm.nih.gov/pubmed/8406878




www.ncbi.nlm.nih.gov/pubmed/8005219




www.ncbi.nlm.nih.gov/pubmed/10030131

And more references can be found here:www.reocities.com/HotSprings/Oasis/6455/western-blot.txt

So I'm still a bit confused on whether the Bands 23- 25 are positive or negative on your test, but if they are positive or IND, it indicates OspC (Outer Surface Protein "C") and is specific for Lyme (Bb)

I hope this helps some.

The one and only LLMD that I saw was Dr. Edwin Masters (RIP) and that's how Master's Disease got it's name. He was a wonderful, caring man!! Master's Disease used to be known as STARI.

For those that don't know, Master's Disease is a Lyme like illness (think just different strains of Borrelia{Lyme}) that can be healed with Lyme treatments.

I hope your healing goes smoothly!!

Dr. Masters passed away and when I saw him in 2007 the only person he was working with was his son - are you seeing his son????

Yes. I don't know how long my LLMD worked with Dr. Masters.

Yes, I am