Posted 9/16/2015 8:10 PM (GMT 0)
Look at it this way.
IgM for current infections
IgG for current infections or previous infections, and could also mean chronic.
That result is highly indicative of history of an infection, and would lean towards a current/active infection to some degree.
One + is a low positive, and ++ is medium, and +++ is high.
IND means indeterminate. That means there was some reaction recorded, but didn't meet the threshold to be positive on that band. So there was something there.
The ** bands are Borrelia specific. The IGM would likely have been IGENEX positive if the 39 band was at least + and not IND. So the IGM is borderline, but the amount of reactivity would lend to a high index of suspicion for a current infection, even if just mild.
See below info for help, as well as the help links on the front page.
COPY/PASTE from http://www.anapsid.org/lyme/wb.html
IgM antibodies are the first antibodies to be produced in the body in response to an infection, and is produced in great quantity. IgM antibodies are large, up to six times larger than the IgG antibodies. IgM antibodies, when present in high numbers, represent a new active infection or an existing infection that has become reactivated. Over time, the number of IgM antibodies will decline as the active infection is resolved.
IgG antibodies are produced once an infection has been going on for a while, and may be present after the infection has been resolved. Generally speaking, the presence of IgG antibodies to an organism when accompanied by a negative IgM test for the same organism means that the person was exposed to that organism at one time and developed antibodies to it, but does not have a current active infection of that organism. When it comes to Borrelia burgdorferi (Bb), the organism responsible for Lyme disease, that is not necessarily the case.
To recap, depending on the numbers,
•IgM is a sign of a current infection.
•IgG is a sign of a current infection, or of a past exposure to or past infection by the organism.
COPY/PASTE from http://www.igenex.com/Website/#
IGeneX has several years of clinical data that support more liberal reporting criteria.10 In addition, current studies show that the CDC/ASTPHLD criteria miss some patients with culture-proven erythema migrans (EM).5,11 Both the IGeneX and the CDC/ASTPHLD criteria are included on the IGeneX report form sent to the physician. 3,5,8,9 The CDC/ASTPHLD criteria for positive results are 5 of the following 10 antigenic bands: 18 kDa, 23-25 kDa (Osp C); 28 kDa, 30 kDa, 39 kDa; 41 kDa, 45 kDa, 58 Kda, 66 KDa, and/or 83-93 kDa. IGeneX criteria for positive result is 2 of the following 6 bands: 23-25kDa, 31 kDa (Osp A), the 34 kDa (Osp B), 39 kDa, 41kDa and/or the 83-93 kDa. 31kDa and 34kDa antigens are included to the criteria due to their importance in the recurrent and/or persistent disease period. IGeneX criteria of is 96% specific for exposure to B. burgdorferi.
A positive IgG result with clinical history may be indicative of Lyme disease. Patients with other spirochetal disease and/or who test positive for rheumatoid factor or Epstein Barr virus may have cross-reacting antibodies. A positive response in this, as in any antibody assay, indicates sensitization, not necessarily active disease. 12
So, per this information, the IgM would be more indicative of a current infection (the IND on 39 is preventing the positive result). 39 and 41 are specific to borrelia/spirochetes. You are positive for these or show some reaction (IND).
It would be a safe bet to treat and retest later. Perhaps even an antibiotic challenge, and the retest.
If I was a provider, I'd be okay with treating this if you were are showing signs and symptoms. This would validate a clinical diagnosis in my eyes.
Hopefully this helped you.