Can someone help with Igenex results?

If anyone can help
Me with these Igenex results I would be very grateful

Igm

Positive 23-25

31 and 41 IND

Igg

2 pluses 31 & 41

39 IND

58 positive

It says indeterminate - could I still have LYME with these results? (I have never received the vaccine)

Thanku!!!!

Hi Willowgirl!
Welcome to our community! I'm so glad you found us.

For your test results, here is the site that I use to help interpret them:www.oocities.org/hotsprings/oasis/6455/western-blot.txt You can go there to find supporting Pubmed articles showing what these bands represent.

An IgM result means that you have an active infection. It once was thought to mean an 'early' infection, but has since been revised. IgG means that the infection is at a later stage.

The more +'s you have beside a number, the stronger the reaction.

IND means indeterminate - not negative, but not quite strong enough to be "fully positive". But it means that you reacted on those bands and should be considered, especially when they are Lyme specific bands.

A "Lyme specific band" means specific for Borrelia Burgdorferi, sensu stricto - Lyme disease in the strictest sense. There are only two on the over 300 known strains of Lyme that is considered Bb, ss. Borrelia burgdorferi and Borrelia mayonii. Nothing else will turn a Lyme specific band positive other than Lyme disease - - even though there are over 100 different strains of Borrelia in the US that cause human illness.

Bands 18 & 41 (whether in IgM or IgG) are indicative of the tail of the bacteria, which can cross react with other Spirochetal bacteria such as Relapsing Fever, Pintas and Yaws, and Syphilis.

For some reason that I have never been able to find out, suddenly some are questioning Band 31 as a Lyme specific band, yet we have plenty of scientific articles that say it is:
Band 31:
www.ncbi.nlm.nih.gov/pubmed/1520966


www.ncbi.nlm.nih.gov/pubmed/9440203


www.ncbi.nlm.nih.gov/pubmed/8406878


www.ncbi.nlm.nih.gov/pubmed/8005219


www.ncbi.nlm.nih.gov/pubmed/10030131


And more references can be found here:
www.reocities.com/HotSprings/Oasis/6455/western-blot.txt

So an explanation of those bands that you tested positive or IND for:

Bands 23 - 25 indicated Osp C (Outer Surface Protein "C") with band 25 being Lyme specific.

Band 31 indicates OspA (Outer Surface Protein "A") and as indicated above, is Lyme specific.

Band 39 indicates BmpA (Bacterial Membrane Protein "A") and is Lyme specific.

Band 58 is thought to be Borrelia Afzelii, a European strain of Lyme that is being seen more and more here in the US.

You most certainly do have Lyme disease according to these test results, especially if you are having symptoms - which you didn't mention if you were or not.

​If you haven't ​yet​, it would be helpful for you to start with reading through the thread at the top of the forum titled,"New to Lyme?...Start here!!", as it is packed full of important information, symptom lists, helpful links and pdf's, how to detox when one has these infections, information on probiotics and much more. And this is another good list of possible detoxing routines: www.tiredoflyme.com/detox-methods.html


For information on finding a​n ILADS ​(International Lyme and Associated Diseases Society)​ trained​ Lyme Literate Medical Doctor(LLMD) in your area, you will need to enable your email option in your profile in order to receive any recommendations, as we don't allow doctor's names and contact info to be posted on the forum for several reasons. You can enable your email option in your profile, under 'edit profile'. Be sure to click the submit button to actually save your preference.


​You can send me an email by clicking on my screen name or the small blue envelope under my screen name. I may have contact information for some LLMD's in your area as well.​ ​Please include your state (or province) and area that you would like to find a LLMD in and I will be happy to share the names I have.​


You can email the Tick-Borne Disease Alliance at [email protected]​ for LLMD referrals and you can go to ​tbdalliance.org​​ to learn more about these infections.


You can go to The Lyme Disease Association and search for LLMD's 3 times in a month. You have to register first. Here is the link:
www.lymediseaseassociation.org/index.php?option=com_content&view=article&id=277&Itemid=74​​


ILADS has their own referral system as well:
ilads.org/ilads_media/physician-referral/

And a new resource: www.LymeDoc.org


​ You will want to find an ILADS trained doctor, not one that has self proclaimed themselves as a LLMD or an ID Doc (Infectious Disease Doctor), as ID docs believe Lyme is hard to catch and easy to treat, and don't believe in the reality of chronic Lyme. Go to the ILADS site to read the new (2014) Treatment guidelines to get you started on your healing journey:
www.ilads.org/lyme/treatment-guideline.php

Thanku for writing me I am working with a company right now that drew a lot of tests they are llmd but im seeing another one on Thursday I just feel awful and inconclusive just doesn't MAKe sense to me - im new to all of this - thank you for writing me back!

That, was your very first herx! That will happen for many who start treatments. You will need to start detoxing and making sure that you eat very healthy - no sugar (increases the risk of Candida quite a bit) and start helping your body to detox. We have some great ideas in our "New to Lyme? Start here!" thread that sits at the top of the forum and there are some great ones in this list as well:
www.tiredoflyme.com/detox-methods.html

This is an article that will help explain what happened and why we herx: www.benbrew.com/lb/lyme5.pdf

While I understand that you don't want to treat something you don't have, you do have Lyme disease. And since you are symptomatic, you definitely need treatment. Why were you told to stop the Doxy? Are you getting ready to start something else?

Not treating when you have test results like this and are symptomatic will lead to serious dysfunction and more and more issues happening until you can't function at all. I ended up going 40 years without a proper diagnosis and treatment - so I know very well what happens when a person doesn't get the treatments they really do need.

I also tested positive for mycoplasma, ebv, hhv-6 - but not chlam pneum. I started taking azithromycin with plaquenil in January (along with a full herbal protocol) and have noticed improvements after a few months. Azithromycin treats both Lyme and Mycoplasma.

Most of my symptoms are neuro as well. I was IND on Igenex western blot but did the epitope test on band 31 and it came back positive.

The epitope test is through Igenex. They keep your blood sample for awhile (not sure how many weeks)

They can do a more sensitive test on band 31 to definitively say it is lyme.

For some reason, there has been a bit of controversy on whether band 31 is lyme specific, or if it cross reacts with some viruses.
This has started recently...as it has always been thought that band 31 IS lyme specific.

From an interview with Dr. Horowitz:

".....supporting that diagnosis by finding borrelia-specific bands on the Western Blot, which show evidence of exposure. This would include finding the 23(OspC), 31(OspA), 34(OspB), 39, and 83-93 kDa bands on the Western Blot."

The interview was in May, 2014.

www.publichealthalert.org/-interview-with-dr-horowitz.html

k07 said...
I think it was around $100 for IGG.

IgeneX keeps your blood for 2 or 3 months in case you want additional tests.

Thanks k07 - good to know they keep it for awhile.

Yes, the Epitope is $100

my symptoms are horrible shocks going all through my head , disorienting wave feelings that change my hearing and disorient me and I wil fall to the groubd , horrible tinnitus, hearing going in a ms out, sleep paralysis, seeing blue light in vision, pulsing going down my left arm into my fingers, buzzing and twitching all from my feet up to thighs , horrible back and neck pain pain, and much much more but mainly it is the disorienting waves and shocks and hearing issues

willowgirl - I am so sorry you have all those horrible symptoms.

Do you have a LLMD appointment yet? If not, please look into that.

Don't worry about the spelling errors...it must be difficult for you to even type anything...

Have you started detoxing?

I met with a llmd yesterday and she pretty much diagnosed me without looking at Igenex results but I fear she didn't know much about the bands - she says I need to go on IV treatment for sure - this would have to be through a home nurse - and today I have my lab review with the doctor who drew the test from AZ - it is very $$ for treatment there but with my horrendous neuro symptoms I dont k ow if it would be smarter to go to a facility where I would be monitored more often it seems like this llmd isn't around much - and my ind result it still bugging me - any thoughts?